Adipose tissue transcriptomics and epigenomics in low birthweight men and controls: role of high-fat overfeeding

Aims/hypothesis Individuals who had a low birthweight (LBW) are at an increased risk of insulin resistance and type 2 diabetes when exposed to high-fat overfeeding (HFO). We studied genome-wide mRNA expression and DNA methylation in subcutaneous adipose tissue (SAT) after 5 days of HFO and after a c...

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Veröffentlicht in:	Diabetologia 2016-04, Vol.59 (4), p.799-812
Hauptverfasser:	Gillberg, Linn, Perfilyev, Alexander, Brøns, Charlotte, Thomasen, Martin, Grunnet, Louise G., Volkov, Petr, Rosqvist, Fredrik, Iggman, David, Dahlman, Ingrid, Risérus, Ulf, Rönn, Tina, Nilsson, Emma, Vaag, Allan, Ling, Charlotte
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Vesicular Transport - genetics Adipose Tissue - metabolism Adult Birth weight Body fat Clinical Medicine Diabetes Diabetes Mellitus, Type 2 - genetics Diet Diet, High-Fat - adverse effects DNA methylation DNA Methylation - genetics Endocrinology and Diabetes Endokrinologi och diabetes Epigenetics Epigenomics Fatty Acid Desaturases - genetics Gene expression Genomes Health care High-fat overfeeding Human Physiology Humans Infant, Low Birth Weight - physiology Insulin resistance Internal Medicine Klinisk medicin Low birthweight Male Medical and Health Sciences Medicin och hälsovetenskap Medicine Medicine & Public Health Metabolic Diseases Metabolic disorders Metabolism Musculoskeletal system Nerve Tissue Proteins - genetics Nutrition research Obesity Transcriptome - genetics Type 2 diabetes Young Adult
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Zusammenfassung:	Aims/hypothesis Individuals who had a low birthweight (LBW) are at an increased risk of insulin resistance and type 2 diabetes when exposed to high-fat overfeeding (HFO). We studied genome-wide mRNA expression and DNA methylation in subcutaneous adipose tissue (SAT) after 5 days of HFO and after a control diet in 40 young men, of whom 16 had LBW. Methods mRNA expression was analysed using Affymetrix Human Gene 1.0 ST arrays and DNA methylation using Illumina 450K BeadChip arrays. Results We found differential DNA methylation at 53 sites in SAT from LBW vs normal birthweight (NBW) men (false discovery rate
ISSN:	0012-186X 1432-0428 1432-0428
DOI:	10.1007/s00125-015-3852-9