Effect of systemically increasing human full-length Klotho on glucose metabolism in db/db mice

Highlights • We found that by increasing the circulating levels of Klotho there is a decrease in blood glucose. • The effect is mediated by increased insulin secretion. • There is no change in the insulin sensitivity. • Klotho may have a hormonal effect on beta cells.

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Bibliographische Detailangaben
Veröffentlicht in:	Diabetes research and clinical practice 2016-03, Vol.113, p.208-210
Hauptverfasser:	Forsberg, E.A, Olauson, H, Larsson, T, Catrina, S.B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - metabolism Carbohydrate Metabolism Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - therapy Endocrinology & Metabolism Genetic Therapy Glucose Glucuronidase - genetics Humans Insulin - blood Insulin and db/db mouse Klotho Liver Liver - metabolism Male Mice
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Beschreibung
Zusammenfassung:	Highlights • We found that by increasing the circulating levels of Klotho there is a decrease in blood glucose. • The effect is mediated by increased insulin secretion. • There is no change in the insulin sensitivity. • Klotho may have a hormonal effect on beta cells.
ISSN:	0168-8227 1872-8227
DOI:	10.1016/j.diabres.2016.01.006