In vivo evidence of a functional association between immune cells in blood and brain in healthy human subjects

In vivo evidence of a functional association between immune cells in blood and brain in healthy human subjects

Highlights • We examined the immune cell marker TSPO in healthy human subjects using PET. • A strong positive correlation was observed between TSPO binding in brain and blood cells. • Associations were observed both at baseline and between two PET measurements. • Change in blood leukocyte counts was...

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Veröffentlicht in:Brain, behavior, and immunity behavior, and immunity, 2016-05, Vol.54, p.149-157
Hauptverfasser: Kanegawa, Naoki, Collste, Karin, Forsberg, Anton, Schain, Martin, Arakawa, Ryosuke, Jucaite, Aurelija, Lekander, Mats, Olgart Höglund, Caroline, Kosek, Eva, Lampa, Jon, Halldin, Christer, Farde, Lars, Varrone, Andrea, Cervenka, Simon
Format: Artikel
Sprache:eng
Schlagworte:
[11C]PBR28
[C-11]PBR28
Adult
Age Factors
Allergy and Immunology
Biomarkers - blood
Biomarkers - metabolism
Blood immune cells
Blood-Brain Barrier - immunology
Blood-Brain Barrier - metabolism
Brain - immunology
Brain - metabolism
Carbon Radioisotopes - analysis
Cohort Studies
Female
Humans
Leukocyte Count
Male
Microglia
Microglia - immunology
Microglia - metabolism
Middle Aged
PET
Positron-Emission Tomography - methods
Protein Binding
Psychiatry
Radiopharmaceuticals - analysis
Receptors, GABA - blood
Receptors, GABA - immunology
Receptors, GABA - metabolism
Translocator protein
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Beschreibung
Zusammenfassung:Highlights • We examined the immune cell marker TSPO in healthy human subjects using PET. • A strong positive correlation was observed between TSPO binding in brain and blood cells. • Associations were observed both at baseline and between two PET measurements. • Change in blood leukocyte counts was correlated to change in TSPO binding. • The results indicate an association between immunological cells in blood and brain.
ISSN:0889-1591
1090-2139
1090-2139
DOI:10.1016/j.bbi.2016.01.019