Lipid mediators as regulators of human ILC2 function in allergic diseases

Highlights • ILC2 play an important role in type 2 immunity. • IL-12 drives ILC2–ILC1 plasticity. • Bioactive lipids control ILC2 function and accumulation. • ILC2 may provide a novel therapeutic target in the treatment of allergic diseases.

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Bibliographische Detailangaben
Veröffentlicht in:	Immunology letters 2016-11, Vol.179, p.36-42
Hauptverfasser:	Konya, Viktoria, Mjösberg, Jenny
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Anti-Asthmatic Agents - pharmacology Anti-Asthmatic Agents - therapeutic use Asthma Atopic dermatitis Cell Plasticity - immunology Humans Hypersensitivity - drug therapy Hypersensitivity - genetics Hypersensitivity - immunology Hypersensitivity - metabolism Immunity, Innate - drug effects Inflammation Mediators - metabolism Innate lymphoid cells Leukotrienes Leukotrienes - metabolism Lipids Lipoxins Lipoxins - metabolism Lymphocyte Subsets - cytology Lymphocyte Subsets - drug effects Lymphocyte Subsets - immunology Lymphocyte Subsets - metabolism Molecular Targeted Therapy Prostaglandins Prostaglandins - metabolism
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Beschreibung
Zusammenfassung:	Highlights • ILC2 play an important role in type 2 immunity. • IL-12 drives ILC2–ILC1 plasticity. • Bioactive lipids control ILC2 function and accumulation. • ILC2 may provide a novel therapeutic target in the treatment of allergic diseases.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2016.07.006