The translocator protein gene is associated with symptom severity and cerebral pain processing in fibromyalgia

Highlights • Glia activation is associated with up-regulation of TSPO in chronic pain. • Pain and fibromyalgia (FM) symptoms were associated with a TSPO polymorphism. • A TSPO/serotonin transporter gene-to-gene interaction influenced FM pain. • TSPO affected the emotional-motivational components of...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2016-11, Vol.58, p.218-227
Hauptverfasser:	Kosek, Eva, Martinsen, Sofia, Gerdle, Björn, Mannerkorpi, Kaisa, Löfgren, Monika, Bileviciute-Ljungar, Indre, Fransson, Peter, Schalling, Martin, Ingvar, Martin, Ernberg, Malin, Jensen, Karin B
Format:	Artikel
Sprache:	eng
Schlagworte:	18 kda tspo 5-HTTLPR Adult Allergy and Immunology benzodiazepine-receptor Brain - physiopathology Brain Mapping central inflammation central-nervous-system Female Fibromyalgia Fibromyalgia - genetics Fibromyalgia - physiopathology functional connectivity Functional magnetic resonance Functional magnetic resonance imaging Gene-to-gene interactions Genetic polymorfisms Genotype Humans Immunology Magnetic Resonance Imaging Male Medicin och hälsovetenskap Middle Aged mitochondrial dysfunction Neural Pathways - physiopathology neuropathic pain Neurosciences Neurosciences & Neurology Neurovetenskaper Pain - genetics Pain Measurement Pain Perception - physiology Polymorphism, Genetic Psychiatry Receptors, GABA - genetics Receptors, GABA - metabolism rs6971 SCL6A4 Serotonin Serotonin Plasma Membrane Transport Proteins - genetics Serotonin Plasma Membrane Transport Proteins - metabolism Serotonin transporter serotonin transporter gene Severity of Illness Index substance-p therapeutic target Translocator protein Young Adult
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Beschreibung
Zusammenfassung:	Highlights • Glia activation is associated with up-regulation of TSPO in chronic pain. • Pain and fibromyalgia (FM) symptoms were associated with a TSPO polymorphism. • A TSPO/serotonin transporter gene-to-gene interaction influenced FM pain. • TSPO affected the emotional-motivational components of pain perception in FM. • TSPO may be a new target for drug development in chronic widespread pain.
ISSN:	0889-1591 1090-2139 1090-2139
DOI:	10.1016/j.bbi.2016.07.150