Analysis with the exome array identifies multiple new independent variants in lipid loci

It has been hypothesized that low frequency (1-5% minor allele frequency (MAF)) and rare (1000-fold more significant than the previous sentinel variant and not in close LD (six had MAF

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Bibliographische Detailangaben
Veröffentlicht in:	Human molecular genetics 2016-09, Vol.25 (18), p.4094-4106
Hauptverfasser:	Kanoni, Stavroula, Masca, Nicholas G D, Stirrups, Kathleen E, Varga, Tibor V, Warren, Helen R, Scott, Robert A, Southam, Lorraine, Zhang, Weihua, Yaghootkar, Hanieh, Müller-Nurasyid, Martina, Couto Alves, Alexessander, Strawbridge, Rona J, Lataniotis, Lazaros, An Hashim, Nikman, Besse, Céline, Boland, Anne, Braund, Peter S, Connell, John M, Dominiczak, Anna, Farmaki, Aliki-Eleni, Franks, Stephen, Grallert, Harald, Jansson, Jan-Håkan, Karaleftheri, Maria, Keinänen-Kiukaanniemi, Sirkka, Matchan, Angela, Pasko, Dorota, Peters, Annette, Poulter, Neil, Rayner, Nigel W, Renström, Frida, Rolandsson, Olov, Sabater-Lleal, Maria, Sennblad, Bengt, Sever, Peter, Shields, Denis, Silveira, Angela, Stanton, Alice V, Strauch, Konstantin, Tomaszewski, Maciej, Tsafantakis, Emmanouil, Waldenberger, Melanie, Blakemore, Alexandra I F, Dedoussis, George, Escher, Stefan A, Kooner, Jaspal S, McCarthy, Mark I, Palmer, Colin N A, Hamsten, Anders, Caulfield, Mark J, Frayling, Timothy M, Tobin, Martin D, Jarvelin, Marjo-Riitta, Zeggini, Eleftheria, Gieger, Christian, Chambers, John C, Wareham, Nick J, Munroe, Patricia B, Franks, Paul W, Samani, Nilesh J, Deloukas, Panos
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Association Studies Basic Medicine Biochemistry, Molecular Biology Child Cholesterol, HDL - blood Cholesterol, HDL - genetics Cholesterol, LDL - blood Cholesterol, LDL - genetics Exome - genetics Gene Frequency Genetics Genome-Wide Association Study Human genetics Humans Life Sciences Lipid Metabolism - genetics Lipids - blood Lipids - genetics Medical and Health Sciences Medical Genetics Medicin och hälsovetenskap Medicinsk genetik Medicinska och farmaceutiska grundvetenskaper Middle Aged Molecular biology Polymorphism, Single Nucleotide Triglycerides - blood Triglycerides - genetics White People
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Beschreibung
Zusammenfassung:	It has been hypothesized that low frequency (1-5% minor allele frequency (MAF)) and rare (1000-fold more significant than the previous sentinel variant and not in close LD (six had MAF
ISSN:	0964-6906 1460-2083 1460-2083
DOI:	10.1093/hmg/ddw227