Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study
A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter seri...
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| creator | Wang, Lisa Heckman, Michael G. Aasly, Jan O. Annesi, Grazia Bozi, Maria Chung, Sun Ju Clarke, Carl Crosiers, David Eckstein, Gertrud Garraux, Gaetan Hadjigeorgiou, Georgios M. Hattori, Nobu Jeon, Beom Kim, Yun J. Kubo, Masato Lesage, Suzanne Lin, Juei Jueng Lynch, Timothy Lichtner, Peter Mellick, George D. Mok, Vincent Morrison, Karin E. Quattrone, Aldo Satake, Wataru Silburn, Peter A. Stefanis, Leonidas Stockton, Joanne D. Tan, Eng King Toda, Tatsushi Brice, Alexis Van Broeckhoven, Christine Uitti, Ryan J. Wirdefeldt, Karin Wszolek, Zbigniew Xiromerisiou, Georgia Maraganore, Demetrius M. Gasser, Thomas Krüger, Rejko Farrer, Matthew J. Ross, Owen A. Sharma, Manu |
| description | A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted. |
| doi_str_mv | 10.1016/j.neurobiolaging.2016.09.022 |
| format | Article |
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Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/j.neurobiolaging.2016.09.022</identifier><identifier>PMID: 27814993</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Epistasis, Genetic ; Epistasis, Genetic - genetics ; Genetic Association Studies ; Genetic epidemiology ; Genetic Loci ; Genetic Loci - genetics ; Genetic Predisposition to Disease ; Genetic Predisposition to Disease - genetics ; Genetic Variation ; Genetic Variation - genetics ; Human health and pathology ; Humans ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - genetics ; Life Sciences ; LRRK2 ; Multicenter Studies as Topic ; PARK16 ; Parkinson Disease ; Parkinson Disease - genetics ; Parkinson's disease ; Risk</subject><ispartof>Neurobiology of aging, 2017-01, Vol.49, p.217.e1-217.e4</ispartof><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c578t-e0fa80a10be73e27acc91355616e061d1b4c9423b7d09d71118195111ae3c4ee3</citedby><cites>FETCH-LOGICAL-c578t-e0fa80a10be73e27acc91355616e061d1b4c9423b7d09d71118195111ae3c4ee3</cites><orcidid>0000-0002-0941-3990</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0197458016302366$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,550,776,780,881,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27814993$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.sorbonne-universite.fr/hal-04590351$$DView record in HAL$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:135276236$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Lisa</creatorcontrib><creatorcontrib>Heckman, Michael G.</creatorcontrib><creatorcontrib>Aasly, Jan O.</creatorcontrib><creatorcontrib>Annesi, Grazia</creatorcontrib><creatorcontrib>Bozi, Maria</creatorcontrib><creatorcontrib>Chung, Sun Ju</creatorcontrib><creatorcontrib>Clarke, Carl</creatorcontrib><creatorcontrib>Crosiers, David</creatorcontrib><creatorcontrib>Eckstein, Gertrud</creatorcontrib><creatorcontrib>Garraux, Gaetan</creatorcontrib><creatorcontrib>Hadjigeorgiou, Georgios M.</creatorcontrib><creatorcontrib>Hattori, Nobu</creatorcontrib><creatorcontrib>Jeon, Beom</creatorcontrib><creatorcontrib>Kim, Yun J.</creatorcontrib><creatorcontrib>Kubo, Masato</creatorcontrib><creatorcontrib>Lesage, Suzanne</creatorcontrib><creatorcontrib>Lin, Juei Jueng</creatorcontrib><creatorcontrib>Lynch, Timothy</creatorcontrib><creatorcontrib>Lichtner, Peter</creatorcontrib><creatorcontrib>Mellick, George D.</creatorcontrib><creatorcontrib>Mok, Vincent</creatorcontrib><creatorcontrib>Morrison, Karin E.</creatorcontrib><creatorcontrib>Quattrone, Aldo</creatorcontrib><creatorcontrib>Satake, Wataru</creatorcontrib><creatorcontrib>Silburn, Peter A.</creatorcontrib><creatorcontrib>Stefanis, Leonidas</creatorcontrib><creatorcontrib>Stockton, Joanne D.</creatorcontrib><creatorcontrib>Tan, Eng King</creatorcontrib><creatorcontrib>Toda, Tatsushi</creatorcontrib><creatorcontrib>Brice, Alexis</creatorcontrib><creatorcontrib>Van Broeckhoven, Christine</creatorcontrib><creatorcontrib>Uitti, Ryan J.</creatorcontrib><creatorcontrib>Wirdefeldt, Karin</creatorcontrib><creatorcontrib>Wszolek, Zbigniew</creatorcontrib><creatorcontrib>Xiromerisiou, Georgia</creatorcontrib><creatorcontrib>Maraganore, Demetrius M.</creatorcontrib><creatorcontrib>Gasser, Thomas</creatorcontrib><creatorcontrib>Krüger, Rejko</creatorcontrib><creatorcontrib>Farrer, Matthew J.</creatorcontrib><creatorcontrib>Ross, Owen A.</creatorcontrib><creatorcontrib>Sharma, Manu</creatorcontrib><creatorcontrib>GEOPD Consortium</creatorcontrib><title>Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted.</description><subject>Epistasis, Genetic</subject><subject>Epistasis, Genetic - genetics</subject><subject>Genetic Association Studies</subject><subject>Genetic epidemiology</subject><subject>Genetic Loci</subject><subject>Genetic Loci - genetics</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genetic Variation</subject><subject>Genetic Variation - genetics</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Leucine-Rich Repeat Serine-Threonine Protein Kinase-2</subject><subject>Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - genetics</subject><subject>Life Sciences</subject><subject>LRRK2</subject><subject>Multicenter Studies as Topic</subject><subject>PARK16</subject><subject>Parkinson Disease</subject><subject>Parkinson Disease - genetics</subject><subject>Parkinson's disease</subject><subject>Risk</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNqNkc2O0zAUhSMEYsrAKyAvkIBFgm8SxzFiU43mB00lRhWsLce57bhN7WInHfUheOdxSBlpdqyudfSdc698kuQD0AwoVF82mcXBu8a4Tq2NXWd5VDMqMprnL5IZMFanUAr-MplREDwtWU3PkjchbCilvOTV6-Qs53VERDFL_lweVDeo3jhL3Ir090iM7dEr_VdqsH9AtGSxXN7mRNmW3M2Xt1CRzmkTSdJihHfGxkOIN2E7htwpvzU2OPsxkNYEVAG_Rq_qjsGEEVCkU36NZDd0vdE47iOhH9rj2-TVSnUB353mefLr6vLnxU26-HH9_WK-SDXjdZ8iXamaKqAN8gJzrrQWUDBWQYW0ghaaUosyLxreUtFyAKhBsDgUFrpELM6TdMoND7gfGrn3Zqf8UTpl5EnaxhdKRiEXLPKfJ_5edc_gm_lCjhotmaAFgwNE9tPE7r37PWDo5c4EjV2nLLohSKiLihcFrfKIfptQ7V0IHldP2UDlWLbcyOdly7FsSYWMZUf7-9Omodlh-2T-124EriYA418eDHoZtEGrsTUedS9bZ_5v0yMkDsRb</recordid><startdate>201701</startdate><enddate>201701</enddate><creator>Wang, Lisa</creator><creator>Heckman, Michael G.</creator><creator>Aasly, Jan O.</creator><creator>Annesi, Grazia</creator><creator>Bozi, Maria</creator><creator>Chung, Sun Ju</creator><creator>Clarke, Carl</creator><creator>Crosiers, David</creator><creator>Eckstein, Gertrud</creator><creator>Garraux, Gaetan</creator><creator>Hadjigeorgiou, Georgios M.</creator><creator>Hattori, Nobu</creator><creator>Jeon, Beom</creator><creator>Kim, Yun J.</creator><creator>Kubo, Masato</creator><creator>Lesage, Suzanne</creator><creator>Lin, Juei Jueng</creator><creator>Lynch, Timothy</creator><creator>Lichtner, Peter</creator><creator>Mellick, George D.</creator><creator>Mok, Vincent</creator><creator>Morrison, Karin E.</creator><creator>Quattrone, Aldo</creator><creator>Satake, Wataru</creator><creator>Silburn, Peter A.</creator><creator>Stefanis, Leonidas</creator><creator>Stockton, Joanne D.</creator><creator>Tan, Eng King</creator><creator>Toda, Tatsushi</creator><creator>Brice, Alexis</creator><creator>Van Broeckhoven, Christine</creator><creator>Uitti, Ryan J.</creator><creator>Wirdefeldt, Karin</creator><creator>Wszolek, Zbigniew</creator><creator>Xiromerisiou, Georgia</creator><creator>Maraganore, Demetrius M.</creator><creator>Gasser, Thomas</creator><creator>Krüger, Rejko</creator><creator>Farrer, Matthew J.</creator><creator>Ross, Owen A.</creator><creator>Sharma, Manu</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0002-0941-3990</orcidid></search><sort><creationdate>201701</creationdate><title>Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study</title><author>Wang, Lisa ; Heckman, Michael G. ; Aasly, Jan O. ; Annesi, Grazia ; Bozi, Maria ; Chung, Sun Ju ; Clarke, Carl ; Crosiers, David ; Eckstein, Gertrud ; Garraux, Gaetan ; Hadjigeorgiou, Georgios M. ; Hattori, Nobu ; Jeon, Beom ; Kim, Yun J. ; Kubo, Masato ; Lesage, Suzanne ; Lin, Juei Jueng ; Lynch, Timothy ; Lichtner, Peter ; Mellick, George D. ; Mok, Vincent ; Morrison, Karin E. ; Quattrone, Aldo ; Satake, Wataru ; Silburn, Peter A. ; Stefanis, Leonidas ; Stockton, Joanne D. ; Tan, Eng King ; Toda, Tatsushi ; Brice, Alexis ; Van Broeckhoven, Christine ; Uitti, Ryan J. ; Wirdefeldt, Karin ; Wszolek, Zbigniew ; Xiromerisiou, Georgia ; Maraganore, Demetrius M. ; Gasser, Thomas ; Krüger, Rejko ; Farrer, Matthew J. ; Ross, Owen A. ; Sharma, Manu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c578t-e0fa80a10be73e27acc91355616e061d1b4c9423b7d09d71118195111ae3c4ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Epistasis, Genetic</topic><topic>Epistasis, Genetic - 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| fulltext | fulltext |
| identifier | ISSN: 0197-4580 |
| ispartof | Neurobiology of aging, 2017-01, Vol.49, p.217.e1-217.e4 |
| issn | 0197-4580 1558-1497 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_501295 |
| source | MEDLINE; Elsevier ScienceDirect Journals; SWEPUB Freely available online |
| subjects | Epistasis, Genetic Epistasis, Genetic - genetics Genetic Association Studies Genetic epidemiology Genetic Loci Genetic Loci - genetics Genetic Predisposition to Disease Genetic Predisposition to Disease - genetics Genetic Variation Genetic Variation - genetics Human health and pathology Humans Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - genetics Life Sciences LRRK2 Multicenter Studies as Topic PARK16 Parkinson Disease Parkinson Disease - genetics Parkinson's disease Risk |
| title | Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T12%3A33%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20the%20interaction%20between%20LRRK2%20and%20PARK16%20loci%20in%20determining%20risk%20of%20Parkinson's%20disease:%20analysis%20of%20a%20large%20multicenter%20study&rft.jtitle=Neurobiology%20of%20aging&rft.au=Wang,%20Lisa&rft.aucorp=GEOPD%20Consortium&rft.date=2017-01&rft.volume=49&rft.spage=217.e1&rft.epage=217.e4&rft.pages=217.e1-217.e4&rft.issn=0197-4580&rft.eissn=1558-1497&rft_id=info:doi/10.1016/j.neurobiolaging.2016.09.022&rft_dat=%3Cproquest_swepu%3E1836733062%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1836733062&rft_id=info:pmid/27814993&rft_els_id=S0197458016302366&rfr_iscdi=true |