Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study

A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter seri...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neurobiology of aging 2017-01, Vol.49, p.217.e1-217.e4
Hauptverfasser:	Wang, Lisa, Heckman, Michael G., Aasly, Jan O., Annesi, Grazia, Bozi, Maria, Chung, Sun Ju, Clarke, Carl, Crosiers, David, Eckstein, Gertrud, Garraux, Gaetan, Hadjigeorgiou, Georgios M., Hattori, Nobu, Jeon, Beom, Kim, Yun J., Kubo, Masato, Lesage, Suzanne, Lin, Juei Jueng, Lynch, Timothy, Lichtner, Peter, Mellick, George D., Mok, Vincent, Morrison, Karin E., Quattrone, Aldo, Satake, Wataru, Silburn, Peter A., Stefanis, Leonidas, Stockton, Joanne D., Tan, Eng King, Toda, Tatsushi, Brice, Alexis, Van Broeckhoven, Christine, Uitti, Ryan J., Wirdefeldt, Karin, Wszolek, Zbigniew, Xiromerisiou, Georgia, Maraganore, Demetrius M., Gasser, Thomas, Krüger, Rejko, Farrer, Matthew J., Ross, Owen A., Sharma, Manu
Format:	Artikel
Sprache:	eng
Schlagworte:	Epistasis, Genetic Epistasis, Genetic - genetics Genetic Association Studies Genetic epidemiology Genetic Loci Genetic Loci - genetics Genetic Predisposition to Disease Genetic Predisposition to Disease - genetics Genetic Variation Genetic Variation - genetics Human health and pathology Humans Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - genetics Life Sciences LRRK2 Multicenter Studies as Topic PARK16 Parkinson Disease Parkinson Disease - genetics Parkinson's disease Risk
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted.
ISSN:	0197-4580 1558-1497
DOI:	10.1016/j.neurobiolaging.2016.09.022