Methylation of HPA axis related genes in men with hypersexual disorder

Highlights • Patients with hypersexual disorder had reduced levels of methylation in a locus of the CRH gene. • Patients with hypersexual disorder had higher (TNF)-α levels compared to healthy volunteers. • The methylation levels at the identified CRH site, cg23409074, were significantly correlated...

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Veröffentlicht in:	Psychoneuroendocrinology 2017-06, Vol.80, p.67-73
Hauptverfasser:	Jokinen, Jussi, Boström, Adrian E, Chatzittofis, Andreas, Ciuculete, Diana M, Öberg, Katarina Görts, Flanagan, John N, Arver, Stefan, Schiöth, Helgi B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Childhood trauma Corticotropin-Releasing Hormone - genetics Corticotropin-Releasing Hormone - metabolism Cortisol CpG Islands Dexamethasone test DNA Methylation Endocrinology & Metabolism Epigenesis, Genetic - genetics Epigenetics HPA-axis Humans Hypersexual disorder Hypothalamo-Hypophyseal System - physiopathology Interleukin-6 - metabolism Male Methylation Middle Aged Neuroinflammation Pituitary-Adrenal System - physiopathology Psychiatry Receptors, Corticotropin-Releasing Hormone - genetics Receptors, Corticotropin-Releasing Hormone - metabolism Receptors, Glucocorticoid - metabolism Sexual Dysfunctions, Psychological - genetics Sexual Dysfunctions, Psychological - metabolism Sexual Dysfunctions, Psychological - physiopathology Stress, Psychological - metabolism Tacrolimus Binding Proteins - metabolism TNF-alpha Tumor Necrosis Factor-alpha - metabolism xamethasone test
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Zusammenfassung:	Highlights • Patients with hypersexual disorder had reduced levels of methylation in a locus of the CRH gene. • Patients with hypersexual disorder had higher (TNF)-α levels compared to healthy volunteers. • The methylation levels at the identified CRH site, cg23409074, were significantly correlated between blood and four different brain regions.
ISSN:	0306-4530 1873-3360 1873-3360
DOI:	10.1016/j.psyneuen.2017.03.007