The frequency and influence of dementia risk factors in prodromal Alzheimer’s disease

Abstract We investigated whether dementia risk factors were associated with prodromal Alzheimer’s disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer’s Association criteria, and with cognitive decline. 1394 subjects from with Mild Cognitive Impairmen...

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Veröffentlicht in:	Neurobiology of aging 2017-08, Vol.56, p.33-40
Hauptverfasser:	Bos, Isabelle, MSc, Vos, Stephanie J., PhD, Frölich, Lutz, MD, Kornhuber, Johannes, MD, Wiltfang, Jens, MD, PhD, Maier, Wolfgang, MD, Peters, Oliver, MD, Rüther, Eckhart, MD, PhD, Engelborghs, Sebastiaan, MD, PhD, Niemantsverdriet, Ellis, MSc, De Roeck, Ellen Elisa, MSc, Tsolaki, Magda, MD, PhD, Freund-Levi, Yvonne, Johannsen, Peter, MD, PhD, Vandenberghe, Rik, MD, PhD, Lleó, Alberto, MD, PhD, Alcolea, Daniel, MD, PhD, Frisoni, Giovanni B., MD, Galluzzi, Samantha, MD, Nobili, Flavio, MD, Morbelli, Silvia, PhD, Drzezga, Alexander, MD, PhD, Didic, Mira, MD, PhD, van Berckel, Bart N., MD, PhD, Salmon, Eric, MD, PhD, Bastin, Christine, PhD, Dauby, Solene, Santana, Isabel, MD, PhD, Baldeiras, Inês, PhD, de Mendonça, Alexandre, MD, PhD, Silva, Dina, PhD, Wallin, Anders, MD, PhD, Nordlund, Arto, PhD, Coloma, Preciosa M., MD, PhD, Wientzek, Angelika, PhD, Alexander, Myriam, Novak, Gerald P., MD, Gordon, Mark Forrest, MD, the Alzheimer’s Disease Neuroimaging Initiative, Wallin, Åsa K, Hampel, Harald, MD, PhD, Soininen, Hilkka, MD, PhD, Herukka, Sanna-Kaisa, MD, PhD, Scheltens, Philip, MD, PhD, Verhey, Frans R., MD, PhD, Visser, Pieter Jelle, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alcohol Drinking - adverse effects Alzheimer Disease - etiology Alzheimer's disease Alzheimer’s disease risk factors IWG-2 criteria NIA-AA criteria biomarkers prognosis Biomarkers Clinical Medicine Cognition Cognitive Dysfunction - etiology Cognitive science Depression Disease Progression Female Humans Hypercholesterolemia Internal Medicine IWG-2 criteria Klinisk medicin Male Medical and Health Sciences Medicin och hälsovetenskap Middle Aged Neurologi Neurology Neuroscience Neurosciences Neurosciences & behavior Neurosciences & comportement Neurovetenskaper NIA-AA criteria Obesity Prognosis Proportional Hazards Models Psychiatry Psykiatri Risk Factors Sciences sociales & comportementales, psychologie Social & behavioral sciences, psychology
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Zusammenfassung:	Abstract We investigated whether dementia risk factors were associated with prodromal Alzheimer’s disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer’s Association criteria, and with cognitive decline. 1394 subjects from with Mild Cognitive Impairment (MCI) from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of ten risk factors between the subgroups and used Cox-regression to examine the effect of risk factors on cognitive decline. Depression, obesity and hypercholesterolemia occurred more often in individuals with low-AD-likelihood, compared to those with a high-AD-likelihood. Only alcohol use increased the risk of cognitive decline, regardless of AD pathology. These results suggest that traditional risk factors for AD are not associated with prodromal AD or with progression to dementia, among subjects with MCI. Future studies should validate these findings and determine whether risk factors might be of influence at an earlier stage (i.e. preclinical) of AD.
ISSN:	0197-4580 1558-1497 1558-1497
DOI:	10.1016/j.neurobiolaging.2017.03.034