Markers of neuroinflammation and neuronal injury in bipolar disorder: Relation to prospective clinical outcomes

Highlights • Low CSF levels of YKL-40 predicted mania/hypomania. • CSF levels of IL-8 and NF-L did not predict long-term clinical outcomes. • Assessed markers of neuroinflammation did not consistently predict poor clinical outcomes.

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2017-10, Vol.65, p.195-201
Hauptverfasser:	Isgren, Anniella, Sellgren, Carl, Ekman, Carl-Johan, Holmén-Larsson, Jessica, Blennow, Kaj, Zetterberg, Henrik, Jakobsson, Joel, Landén, Mikael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergy and Immunology Biomarkers - blood Biomarkers - cerebrospinal fluid Bipolar disorder Bipolar Disorder - blood Bipolar Disorder - cerebrospinal fluid Bipolar Disorder - diagnosis Bipolar Disorder - metabolism Cerebrospinal fluid Chemokine CCL2 - analysis Chemokine CCL2 - blood Chitinase-3-Like Protein 1 - analysis Chitinase-3-Like Protein 1 - blood Cytokines Cytokines - analysis Disease progression Female Humans Interleukin-8 - analysis Interleukin-8 - blood Klinisk medicin Longitudinal Studies Male Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper Microglia Middle Aged Neurofilament Proteins - analysis Neurofilament Proteins - blood Neuroimmunomodulation - immunology Neuroinflammation Neurons - physiology Neurosciences Neurovetenskaper Prognosis Prospective Studies Psychiatry Psychotic Disorders - metabolism Psykiatri Treatment Outcome
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creator	Isgren, Anniella Sellgren, Carl Ekman, Carl-Johan Holmén-Larsson, Jessica Blennow, Kaj Zetterberg, Henrik Jakobsson, Joel Landén, Mikael
description	Highlights • Low CSF levels of YKL-40 predicted mania/hypomania. • CSF levels of IL-8 and NF-L did not predict long-term clinical outcomes. • Assessed markers of neuroinflammation did not consistently predict poor clinical outcomes.
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analysis</subject><subject>Neurofilament Proteins - blood</subject><subject>Neuroimmunomodulation - immunology</subject><subject>Neuroinflammation</subject><subject>Neurons - physiology</subject><subject>Neurosciences</subject><subject>Neurovetenskaper</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Psychiatry</subject><subject>Psychotic Disorders - metabolism</subject><subject>Psykiatri</subject><subject>Treatment Outcome</subject><issn>0889-1591</issn><issn>1090-2139</issn><issn>1090-2139</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kl-L1DAUxYMo7uzoB_BF-uhLx9ykaRMFQRZdhRXBP88hTW-XzLRNTdqV-famdGYFwX1KuJzfCTfnEPIC6A4olK_3u7p2O0ah2lGxo5Q9IhugiuYMuHpMNlRKlYNQcEEuY9xTSgUH-ZRcMFlIXpZ0Q_wXEw4YYubbbMA5eDe0nel7Mzk_ZGZo1ulguswN-zkc05HVbvSdCVnjog8NhjfZN-xWYvLZGHwc0U7uDjPbucHZBPt5sr7H-Iw8aU0X8fnp3JKfHz_8uPqU33y9_nz1_ia3oqqmHFpEKMDyprQGZVMoYDVPA1WzorWmxFaVFVAuG0YrJmlbcFRCMsaVVAb4luSrb_yN41zrMbjehKP2xunT6JBuqAtVKrHo1X_1aaHmL3QGgZdciBIefut2HnUa3c4LwgQvBUv6V6s-Gf-aMU66d9Fi15kB_Rw1SFVKVfCU1pbAKrXpU2PA9t4cqF46oPc6dUAvHdBU6NSBxLw82c91j809cQ49Cd6uAkwB3DkMOlqHg8XGhZSbbrx70P7dP_Q55AMeMe79HFJb0hY6Mk3196WESweh4hQKWfA_v3vZ_g</recordid><startdate>20171001</startdate><enddate>20171001</enddate><creator>Isgren, Anniella</creator><creator>Sellgren, Carl</creator><creator>Ekman, Carl-Johan</creator><creator>Holmén-Larsson, Jessica</creator><creator>Blennow, Kaj</creator><creator>Zetterberg, Henrik</creator><creator>Jakobsson, Joel</creator><creator>Landén, Mikael</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>F1U</scope></search><sort><creationdate>20171001</creationdate><title>Markers of neuroinflammation and neuronal injury in bipolar disorder: Relation to prospective clinical outcomes</title><author>Isgren, Anniella ; Sellgren, Carl ; Ekman, Carl-Johan ; Holmén-Larsson, Jessica ; Blennow, Kaj ; Zetterberg, Henrik ; Jakobsson, Joel ; Landén, Mikael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c577t-1fee141c3d6cae8d4912b341c9b24fca6ef9671038d207280f43e958223989a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Allergy and Immunology</topic><topic>Biomarkers - 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subjects	Adult Allergy and Immunology Biomarkers - blood Biomarkers - cerebrospinal fluid Bipolar disorder Bipolar Disorder - blood Bipolar Disorder - cerebrospinal fluid Bipolar Disorder - diagnosis Bipolar Disorder - metabolism Cerebrospinal fluid Chemokine CCL2 - analysis Chemokine CCL2 - blood Chitinase-3-Like Protein 1 - analysis Chitinase-3-Like Protein 1 - blood Cytokines Cytokines - analysis Disease progression Female Humans Interleukin-8 - analysis Interleukin-8 - blood Klinisk medicin Longitudinal Studies Male Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper Microglia Middle Aged Neurofilament Proteins - analysis Neurofilament Proteins - blood Neuroimmunomodulation - immunology Neuroinflammation Neurons - physiology Neurosciences Neurovetenskaper Prognosis Prospective Studies Psychiatry Psychotic Disorders - metabolism Psykiatri Treatment Outcome
title	Markers of neuroinflammation and neuronal injury in bipolar disorder: Relation to prospective clinical outcomes
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