Markers of neuroinflammation and neuronal injury in bipolar disorder: Relation to prospective clinical outcomes

Highlights • Low CSF levels of YKL-40 predicted mania/hypomania. • CSF levels of IL-8 and NF-L did not predict long-term clinical outcomes. • Assessed markers of neuroinflammation did not consistently predict poor clinical outcomes.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2017-10, Vol.65, p.195-201
Hauptverfasser:	Isgren, Anniella, Sellgren, Carl, Ekman, Carl-Johan, Holmén-Larsson, Jessica, Blennow, Kaj, Zetterberg, Henrik, Jakobsson, Joel, Landén, Mikael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergy and Immunology Biomarkers - blood Biomarkers - cerebrospinal fluid Bipolar disorder Bipolar Disorder - blood Bipolar Disorder - cerebrospinal fluid Bipolar Disorder - diagnosis Bipolar Disorder - metabolism Cerebrospinal fluid Chemokine CCL2 - analysis Chemokine CCL2 - blood Chitinase-3-Like Protein 1 - analysis Chitinase-3-Like Protein 1 - blood Cytokines Cytokines - analysis Disease progression Female Humans Interleukin-8 - analysis Interleukin-8 - blood Klinisk medicin Longitudinal Studies Male Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper Microglia Middle Aged Neurofilament Proteins - analysis Neurofilament Proteins - blood Neuroimmunomodulation - immunology Neuroinflammation Neurons - physiology Neurosciences Neurovetenskaper Prognosis Prospective Studies Psychiatry Psychotic Disorders - metabolism Psykiatri Treatment Outcome
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Beschreibung
Zusammenfassung:	Highlights • Low CSF levels of YKL-40 predicted mania/hypomania. • CSF levels of IL-8 and NF-L did not predict long-term clinical outcomes. • Assessed markers of neuroinflammation did not consistently predict poor clinical outcomes.
ISSN:	0889-1591 1090-2139 1090-2139
DOI:	10.1016/j.bbi.2017.05.002