Internet delivered Cognitive Behavior Therapy for Antenatal Depression: A Randomised Controlled Trial

Abstract Major depression occurs in 5–10% of pregnancies and is associated with many negative effects for mother and child, yet treatment options are scarce. To our knowledge, this is the first published randomised controlled trial on Internet delivered Cognitive Behavior Therapy (ICBT) for this group. Objective To test the efficacy of a pregnancy adapted version of an existing 10-week ICBT-program for depression as well as assessing acceptability and adherence Design Randomised controlled trial. Setting Online and telephone. Population or Sample Self-referred pregnant women (gestational week 10–28 at intake) currently suffering from major depressive disorder. Methods 42 pregnant women (gestational week 12–28) with major depression were randomised to either treatment as usual (TAU) provided at their antenatal clinic or to ICBT as an add-on to usual care. Main Outcome Measures The primary outcome was depressive symptoms measured with the Montgomery-Åsberg depression rating scale-self report (MADRS-S). The Edinburgh Postnatal Depression Scale and measures of anxiety and sleep were used. Credibility, satisfaction, adherence and utilization were also assessed. Results The ICBT group had significantly lower levels of depressive symptoms post treatment (p