Optimizing bone morphogenic protein 4-mediated human embryonic stem cell differentiation into trophoblast-like cells using fibroblast growth factor 2 and transforming growth factor-β/activin/nodal signalling inhibition

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Veröffentlicht in:	Reproductive biomedicine online 2017-09, Vol.35 (3), p.253-263
Hauptverfasser:	Koel, Mariann, Võsa, Urmo, Krjutškov, Kaarel, Einarsdottir, Elisabet, Kere, Juha, Tapanainen, Juha, Katayama, Shintaro, Ingerpuu, Sulev, Jaks, Viljar, Stenman, Ulf-Hakan, Lundin, Karolina, Tuuri, Timo, Salumets, Andres
Format:	Artikel
Sprache:	eng
Schlagworte:	Activins - genetics Activins - metabolism Bone Morphogenetic Protein 4 - pharmacology bone morphogenic protein 4 Cell Culture Techniques - methods Cell Differentiation - drug effects Cell Differentiation - genetics Cells, Cultured Down-Regulation - drug effects Down-Regulation - genetics fibroblast growth factor 2 Fibroblast Growth Factor 2 - genetics Fibroblast Growth Factor 2 - metabolism human embryonic stem cell Human Embryonic Stem Cells - drug effects Human Embryonic Stem Cells - physiology Humans Medicin och hälsovetenskap Nodal Protein - genetics Nodal Protein - metabolism Obstetrics and Gynecology placenta Signal Transduction - drug effects Signal Transduction - genetics Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism transforming growth factor-β trophoblast cells Trophoblasts - drug effects Trophoblasts - physiology
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Zusammenfassung:	Graphical Abstract Unlabelled image
ISSN:	1472-6483 1472-6491 1472-6491
DOI:	10.1016/j.rbmo.2017.06.003