IgG Endopeptidase in Highly Sensitized Patients Undergoing Transplantation

In this study, an IgG-degrading enzyme derived from Streptococcus pyogenes (IdeS) that cleaves human IgG into F(ab′) 2 and Fc fragments reduced or eliminated donor-specific antibodies and permitted HLA-incompatible renal transplantation.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2017-08, Vol.377 (5), p.442-453
Hauptverfasser:	Jordan, Stanley C, Lorant, Tomas, Choi, Jua, Kjellman, Christian, Winstedt, Lena, Bengtsson, Mats, Zhang, Xiaohai, Eich, Torsten, Toyoda, Mieko, Eriksson, Britt-Marie, Ge, Shili, Peng, Alice, Järnum, Sofia, Wood, Kathryn J, Lundgren, Torbjorn, Wennberg, Lars, Bäckman, Lars, Larsson, Erik, Villicana, Rafael, Kahwaji, Joe, Louie, Sabrina, Kang, Alexis, Haas, Mark, Nast, Cynthia, Vo, Ashley, Tufveson, Gunnar
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies - blood Bacterial Proteins - adverse effects Bacterial Proteins - therapeutic use Clinical trials Complement C1q - immunology Cysteine Endopeptidases - adverse effects Cysteine Endopeptidases - therapeutic use Cytotoxicity Endopeptidases Female Globulins Glucocorticoids Graft rejection Histocompatibility antigen HLA Histocompatibility Testing HLA Antigens - immunology Humans Immunoglobulin A Immunoglobulin G Immunoglobulin G - blood Immunoglobulin G - metabolism Immunoglobulin M Immunoglobulins Immunology Immunosuppression Immunosuppression Therapy - methods Immunotherapy Intravenous administration Kidney diseases Kidney Transplantation Kidneys Male Middle Aged Monoclonal antibodies Mycophenolate mofetil Mycophenolic acid Pathology Perfusion Renal function Rituximab Streptococcus infections Tacrolimus Transplantation Transplantation Immunology Transplants & implants
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Beschreibung
Zusammenfassung:	In this study, an IgG-degrading enzyme derived from Streptococcus pyogenes (IdeS) that cleaves human IgG into F(ab′) 2 and Fc fragments reduced or eliminated donor-specific antibodies and permitted HLA-incompatible renal transplantation.
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa1612567