Breast cancer in young women and prognosis: How important are proliferation markers?

Compared to middle-aged women, young women with breast cancer have a higher risk of systemic disease. We studied expression of proliferation markers in relation to age and subtype and their association with long-term prognosis. Distant disease-free survival (DDFS) was studied in 504 women aged

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Veröffentlicht in:	European journal of cancer (1990) 2017-10, Vol.84, p.278-289
Hauptverfasser:	Fredholm, Hanna, Magnusson, Kristina, Lindström, Linda S., Tobin, Nicholas P., Lindman, Henrik, Bergh, Jonas, Holmberg, Lars, Pontén, Fredrik, Frisell, Jan, Fredriksson, Irma
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Age Factors Aged Biomarkers Breast cancer Breast Neoplasms - chemistry Breast Neoplasms - mortality Breast Neoplasms - pathology Breast Neoplasms - therapy Cancer Cell Proliferation Cyclin Cyclins Cyclins - analysis Disease-Free Survival ErbB-2 protein Female Health risks Humans Immunohistochemistry Kaplan-Meier Estimate Ki-67 Ki-67 Antigen - analysis Luminal Markers Medical prognosis Medical records Middle Aged Population-based Predictive Value of Tests Progesterone Progesterone receptor Prognosis Proportional Hazards Models Receptor, ErbB-2 - analysis Receptors, Estrogen - analysis Receptors, Progesterone - analysis Registries Risk Risk Factors Subgroups Subtype Sweden Time Factors Tissue Array Analysis Treatment Outcome Tumors Women Young
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Zusammenfassung:	Compared to middle-aged women, young women with breast cancer have a higher risk of systemic disease. We studied expression of proliferation markers in relation to age and subtype and their association with long-term prognosis. Distant disease-free survival (DDFS) was studied in 504 women aged
ISSN:	0959-8049 1879-0852 1879-0852
DOI:	10.1016/j.ejca.2017.07.044