Massive apixaban overdose – A comparison of three cases

[...]comparing Barton et al.'s case and Leikin et al.'s case indicates that ingesting a 50% greater amount of apixaban may result in five times higher apixaban concentration during the first 24h (Fig. 1A) [1,4]. [...]all three patients' coagulation tests were only mildly elevated during two days of observation despite massive apixaban ingestions, and none of the patients suffered any serious bleeding (Fig. 1BC). [...]more experiences of apixaban overdose cases are at hand, we recommend careful monitoring of such patients until coagulation tests have normalized.