Reduced CDHR3 expression in children wheezing with rhinovirus

Background Rhinovirus‐induced wheezing in young children has been associated with increased asthma risk at school age. Recently, the transmembrane protein cadherin‐related family member 3 (CDHR3) was identified as the RV‐C receptor and the genetic variant rs6967330 (p.Cys529Tyr) was reported to be a...

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Veröffentlicht in:Pediatric allergy and immunology 2018-03, Vol.29 (2), p.200-206
Hauptverfasser: Stenberg Hammar, Katarina, Niespodziana, Katarzyna, van Hage, Marianne, Kere, Juha, Valenta, Rudolf, Hedlin, Gunilla, Söderhäll, Cilla
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Sprache:eng
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Zusammenfassung:Background Rhinovirus‐induced wheezing in young children has been associated with increased asthma risk at school age. Recently, the transmembrane protein cadherin‐related family member 3 (CDHR3) was identified as the RV‐C receptor and the genetic variant rs6967330 (p.Cys529Tyr) was reported to be associated with enhanced RV‐C binding and increased replication in vitro. The aim of this study was to examine rs6967330 genotypes and mRNA expression of CDHR3 in relation to presence of rhinovirus and clinical symptoms in children with acute wheezing and compare to a group of age‐matched healthy children. Methods rs6967330;G>A was genotyped (n = 216), and CDHR3 mRNA expression was measured in peripheral blood leukocytes (n = 69) from a subgroup of children wheezing with RV infection acute and at a follow‐up visit 2‐3 months later, and in healthy controls. Standardized TaqMan assays were used. Results The risk allele rs6967330‐A was over‐represented in the wheezing group (P 
ISSN:0905-6157
1399-3038
DOI:10.1111/pai.12858