Tacrolimus and Mycophenolate Mofetil as Second-Line Therapies for Pediatric Patients with Autoimmune Hepatitis

Background We studied the efficacy and safety of mycophenolate mofetil (MMF) and tacrolimus as second-line therapy in pediatric patients with autoimmune hepatitis (AIH) who were intolerant or non-responders to standard therapy (corticosteroid and azathioprine). Patients and Methods We performed a re...

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Veröffentlicht in:	Digestive diseases and sciences 2018-05, Vol.63 (5), p.1348-1354
Hauptverfasser:	Efe, Cumali, Taii, Haider Al, Ytting, Henriette, Aehling, Niklas, Bhanji, Rahima A., Hagström, Hannes, Purnak, Tugrul, Muratori, Luigi, Werner, Mårten, Muratori, Paolo, Klintman, Daniel, Schiano, Thomas D., Montano-Loza, Aldo J., Berg, Thomas, Larsen, Fin Stolze, Alkhouri, Naim, Ozaslan, Ersan, Heneghan, Michael A., Yoshida, Eric M., Wahlin, Staffan
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmune hepatitis Biochemistry Care and treatment Children Chronic active hepatitis Cirrhosis Corticosteroids Drug therapy Gastroenterology Health aspects Hepatitis Hepatology Immunosuppressive agents Liver cirrhosis Liver transplantation Liver transplants Medical research Medicine Medicine & Public Health Medicine, Experimental Mycophenolate mofetil Oncology Original Article Pediatric Pediatrics Second-line Tacrolimus Transplant Surgery
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Zusammenfassung:	Background We studied the efficacy and safety of mycophenolate mofetil (MMF) and tacrolimus as second-line therapy in pediatric patients with autoimmune hepatitis (AIH) who were intolerant or non-responders to standard therapy (corticosteroid and azathioprine). Patients and Methods We performed a retrospective study of data from 13 centers in Europe, USA, and Canada. Thirty-eight patients (
ISSN:	0163-2116 1573-2568 1573-2568
DOI:	10.1007/s10620-018-5011-x