Saliva and serum biomarkers in periodontitis and coronary artery disease
Aim Matrix metalloproteinase (MMP)‐8, MMP‐9, tissue inhibitor of matrix metalloproteinase (TIMP)‐1 and myeloperoxidase (MPO) participate in extracellular matrix breakdown both in periodontium and atherosclerotic plaques. We investigated the diagnostic value of serum and saliva biomarkers in periodon...
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| Veröffentlicht in: | Journal of clinical periodontology 2018-09, Vol.45 (9), p.1045-1055 |
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| creator | Lahdentausta, Laura S. J. Paju, Susanna Mäntylä, Päivi Buhlin, Kåre Tervahartiala, Taina Pietiäinen, Milla Alfthan, Henrik Nieminen, Markku S. Sinisalo, Juha Sorsa, Timo Pussinen, Pirkko J. |
| description | Aim
Matrix metalloproteinase (MMP)‐8, MMP‐9, tissue inhibitor of matrix metalloproteinase (TIMP)‐1 and myeloperoxidase (MPO) participate in extracellular matrix breakdown both in periodontium and atherosclerotic plaques. We investigated the diagnostic value of serum and saliva biomarkers in periodontitis and acute coronary syndrome (ACS).
Materials and methods
The population was PAROGENE (n = 481), a random cohort of patients with an indication for coronary angiography. All patients underwent a clinical and radiographic oral examination. Groups consisting of periodontitis versus non‐periodontitis, and ACS versus non‐ACS patients were compared.
Results
Saliva MMP‐8, MMP‐9 and MPO provided significant area‐under‐curve (AUC) values for periodontitis, 0.69 ( |
| doi_str_mv | 10.1111/jcpe.12976 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_487194</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2064785202</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4456-3d5d4e030ab70c959cccca59ef184c4d32c4775bca696b3f143ccb0d3897df713</originalsourceid><addsrcrecordid>eNp9kV9LHDEUxYO06Gr74gcoA32Rwmj-zWTuY1m0WoQKWuhbyCR3IOvsZJrsKPvtG51VodDelxvC7xwO9xByzOgpy3O2siOeMg6q3iMLVlNa0or9ekcWVFBR1qDggBymtKKUKSHEPjngAIrXUC_I5a3p_YMpzOCKhHFaF60PaxPvMabCD8WI0QcXho3f-PRM2RDDYOK2MHGDeTmf0CT8QN53pk_4cbePyM-L87vlZXn949vV8ut1aaWs6lK4yknMwUyrqIUKbB5TAXaskVY6wa1UqmqtyfFa0TEprG2pEw0o1ykmjkg5-6ZHHKdWj9HnuFsdjNe7r_v8Qi0bxUBmHv7JjzG4N9GLkAlgDBoOWXsyazP4e8K00WufLPa9GTBMSXNaS9VUnPKMfv4LXYUpDvkSmrN8eArQNJn6MlM2hpQidq9xGNVPXeqnLvVzlxn-tLOc2jW6V_SlvAywGXj0PW7_Y6W_L2_OZ9M_H6Gq0A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2100109988</pqid></control><display><type>article</type><title>Saliva and serum biomarkers in periodontitis and coronary artery disease</title><source>Access via Wiley Online Library</source><creator>Lahdentausta, Laura S. J. ; Paju, Susanna ; Mäntylä, Päivi ; Buhlin, Kåre ; Tervahartiala, Taina ; Pietiäinen, Milla ; Alfthan, Henrik ; Nieminen, Markku S. ; Sinisalo, Juha ; Sorsa, Timo ; Pussinen, Pirkko J.</creator><creatorcontrib>Lahdentausta, Laura S. J. ; Paju, Susanna ; Mäntylä, Päivi ; Buhlin, Kåre ; Tervahartiala, Taina ; Pietiäinen, Milla ; Alfthan, Henrik ; Nieminen, Markku S. ; Sinisalo, Juha ; Sorsa, Timo ; Pussinen, Pirkko J.</creatorcontrib><description>Aim
Matrix metalloproteinase (MMP)‐8, MMP‐9, tissue inhibitor of matrix metalloproteinase (TIMP)‐1 and myeloperoxidase (MPO) participate in extracellular matrix breakdown both in periodontium and atherosclerotic plaques. We investigated the diagnostic value of serum and saliva biomarkers in periodontitis and acute coronary syndrome (ACS).
Materials and methods
The population was PAROGENE (n = 481), a random cohort of patients with an indication for coronary angiography. All patients underwent a clinical and radiographic oral examination. Groups consisting of periodontitis versus non‐periodontitis, and ACS versus non‐ACS patients were compared.
Results
Saliva MMP‐8, MMP‐9 and MPO provided significant area‐under‐curve (AUC) values for periodontitis, 0.69 (<0.001), 0.66 (<0.001) and 0.68 (<0.001), respectively. Serum MMP‐8, MMP‐9 and MPO levels distinguished ACS from non‐ACS patients with AUCs of 0.73 (<0.001), 0.58 (0.03) and 0.68 (<0.001), respectively. Periodontitis confounded the use of serum MMP‐9 in diagnostics of ACS. Cardiac status complicated the use of saliva TIMP‐1 in periodontal diagnostics. Saliva biomarkers could not be used in ACS diagnosis, and serum biomarkers were not useful in diagnosis of periodontitis.
Conclusions
MMP‐8, MMP‐9, TIMP‐1and MPO are valuable biomarkers for both ACS and periodontitis, but the selection of sample material is crucial; serum is suitable for ACS and saliva for periodontal diagnostic aid.</description><identifier>ISSN: 0303-6979</identifier><identifier>ISSN: 1600-051X</identifier><identifier>EISSN: 1600-051X</identifier><identifier>DOI: 10.1111/jcpe.12976</identifier><identifier>PMID: 29972696</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>acute coronary syndrome ; Acute coronary syndromes ; Angiography ; Arteriosclerosis ; biomarker ; Biomarkers ; Cardiovascular disease ; Coronary artery ; Dentistry ; Diagnosis ; Extracellular matrix ; Gum disease ; Heart diseases ; Matrix metalloproteinase ; Medicin och hälsovetenskap ; Metalloproteinase ; MMP‐8 ; MMP‐9 ; myeloperoxidase ; Periodontitis ; Periodontium ; Peroxidase ; Plaques ; Saliva ; serum ; TIMP‐1 ; Tissue inhibitor of metalloproteinases</subject><ispartof>Journal of clinical periodontology, 2018-09, Vol.45 (9), p.1045-1055</ispartof><rights>2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2018 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4456-3d5d4e030ab70c959cccca59ef184c4d32c4775bca696b3f143ccb0d3897df713</citedby><cites>FETCH-LOGICAL-c4456-3d5d4e030ab70c959cccca59ef184c4d32c4775bca696b3f143ccb0d3897df713</cites><orcidid>0000-0002-4875-0682 ; 0000-0003-4865-660X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjcpe.12976$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjcpe.12976$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29972696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:139119829$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Lahdentausta, Laura S. J.</creatorcontrib><creatorcontrib>Paju, Susanna</creatorcontrib><creatorcontrib>Mäntylä, Päivi</creatorcontrib><creatorcontrib>Buhlin, Kåre</creatorcontrib><creatorcontrib>Tervahartiala, Taina</creatorcontrib><creatorcontrib>Pietiäinen, Milla</creatorcontrib><creatorcontrib>Alfthan, Henrik</creatorcontrib><creatorcontrib>Nieminen, Markku S.</creatorcontrib><creatorcontrib>Sinisalo, Juha</creatorcontrib><creatorcontrib>Sorsa, Timo</creatorcontrib><creatorcontrib>Pussinen, Pirkko J.</creatorcontrib><title>Saliva and serum biomarkers in periodontitis and coronary artery disease</title><title>Journal of clinical periodontology</title><addtitle>J Clin Periodontol</addtitle><description>Aim
Matrix metalloproteinase (MMP)‐8, MMP‐9, tissue inhibitor of matrix metalloproteinase (TIMP)‐1 and myeloperoxidase (MPO) participate in extracellular matrix breakdown both in periodontium and atherosclerotic plaques. We investigated the diagnostic value of serum and saliva biomarkers in periodontitis and acute coronary syndrome (ACS).
Materials and methods
The population was PAROGENE (n = 481), a random cohort of patients with an indication for coronary angiography. All patients underwent a clinical and radiographic oral examination. Groups consisting of periodontitis versus non‐periodontitis, and ACS versus non‐ACS patients were compared.
Results
Saliva MMP‐8, MMP‐9 and MPO provided significant area‐under‐curve (AUC) values for periodontitis, 0.69 (<0.001), 0.66 (<0.001) and 0.68 (<0.001), respectively. Serum MMP‐8, MMP‐9 and MPO levels distinguished ACS from non‐ACS patients with AUCs of 0.73 (<0.001), 0.58 (0.03) and 0.68 (<0.001), respectively. Periodontitis confounded the use of serum MMP‐9 in diagnostics of ACS. Cardiac status complicated the use of saliva TIMP‐1 in periodontal diagnostics. Saliva biomarkers could not be used in ACS diagnosis, and serum biomarkers were not useful in diagnosis of periodontitis.
Conclusions
MMP‐8, MMP‐9, TIMP‐1and MPO are valuable biomarkers for both ACS and periodontitis, but the selection of sample material is crucial; serum is suitable for ACS and saliva for periodontal diagnostic aid.</description><subject>acute coronary syndrome</subject><subject>Acute coronary syndromes</subject><subject>Angiography</subject><subject>Arteriosclerosis</subject><subject>biomarker</subject><subject>Biomarkers</subject><subject>Cardiovascular disease</subject><subject>Coronary artery</subject><subject>Dentistry</subject><subject>Diagnosis</subject><subject>Extracellular matrix</subject><subject>Gum disease</subject><subject>Heart diseases</subject><subject>Matrix metalloproteinase</subject><subject>Medicin och hälsovetenskap</subject><subject>Metalloproteinase</subject><subject>MMP‐8</subject><subject>MMP‐9</subject><subject>myeloperoxidase</subject><subject>Periodontitis</subject><subject>Periodontium</subject><subject>Peroxidase</subject><subject>Plaques</subject><subject>Saliva</subject><subject>serum</subject><subject>TIMP‐1</subject><subject>Tissue inhibitor of metalloproteinases</subject><issn>0303-6979</issn><issn>1600-051X</issn><issn>1600-051X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kV9LHDEUxYO06Gr74gcoA32Rwmj-zWTuY1m0WoQKWuhbyCR3IOvsZJrsKPvtG51VodDelxvC7xwO9xByzOgpy3O2siOeMg6q3iMLVlNa0or9ekcWVFBR1qDggBymtKKUKSHEPjngAIrXUC_I5a3p_YMpzOCKhHFaF60PaxPvMabCD8WI0QcXho3f-PRM2RDDYOK2MHGDeTmf0CT8QN53pk_4cbePyM-L87vlZXn949vV8ut1aaWs6lK4yknMwUyrqIUKbB5TAXaskVY6wa1UqmqtyfFa0TEprG2pEw0o1ykmjkg5-6ZHHKdWj9HnuFsdjNe7r_v8Qi0bxUBmHv7JjzG4N9GLkAlgDBoOWXsyazP4e8K00WufLPa9GTBMSXNaS9VUnPKMfv4LXYUpDvkSmrN8eArQNJn6MlM2hpQidq9xGNVPXeqnLvVzlxn-tLOc2jW6V_SlvAywGXj0PW7_Y6W_L2_OZ9M_H6Gq0A</recordid><startdate>201809</startdate><enddate>201809</enddate><creator>Lahdentausta, Laura S. J.</creator><creator>Paju, Susanna</creator><creator>Mäntylä, Päivi</creator><creator>Buhlin, Kåre</creator><creator>Tervahartiala, Taina</creator><creator>Pietiäinen, Milla</creator><creator>Alfthan, Henrik</creator><creator>Nieminen, Markku S.</creator><creator>Sinisalo, Juha</creator><creator>Sorsa, Timo</creator><creator>Pussinen, Pirkko J.</creator><general>Blackwell Publishing Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><orcidid>https://orcid.org/0000-0002-4875-0682</orcidid><orcidid>https://orcid.org/0000-0003-4865-660X</orcidid></search><sort><creationdate>201809</creationdate><title>Saliva and serum biomarkers in periodontitis and coronary artery disease</title><author>Lahdentausta, Laura S. J. ; Paju, Susanna ; Mäntylä, Päivi ; Buhlin, Kåre ; Tervahartiala, Taina ; Pietiäinen, Milla ; Alfthan, Henrik ; Nieminen, Markku S. ; Sinisalo, Juha ; Sorsa, Timo ; Pussinen, Pirkko J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4456-3d5d4e030ab70c959cccca59ef184c4d32c4775bca696b3f143ccb0d3897df713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>acute coronary syndrome</topic><topic>Acute coronary syndromes</topic><topic>Angiography</topic><topic>Arteriosclerosis</topic><topic>biomarker</topic><topic>Biomarkers</topic><topic>Cardiovascular disease</topic><topic>Coronary artery</topic><topic>Dentistry</topic><topic>Diagnosis</topic><topic>Extracellular matrix</topic><topic>Gum disease</topic><topic>Heart diseases</topic><topic>Matrix metalloproteinase</topic><topic>Medicin och hälsovetenskap</topic><topic>Metalloproteinase</topic><topic>MMP‐8</topic><topic>MMP‐9</topic><topic>myeloperoxidase</topic><topic>Periodontitis</topic><topic>Periodontium</topic><topic>Peroxidase</topic><topic>Plaques</topic><topic>Saliva</topic><topic>serum</topic><topic>TIMP‐1</topic><topic>Tissue inhibitor of metalloproteinases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lahdentausta, Laura S. J.</creatorcontrib><creatorcontrib>Paju, Susanna</creatorcontrib><creatorcontrib>Mäntylä, Päivi</creatorcontrib><creatorcontrib>Buhlin, Kåre</creatorcontrib><creatorcontrib>Tervahartiala, Taina</creatorcontrib><creatorcontrib>Pietiäinen, Milla</creatorcontrib><creatorcontrib>Alfthan, Henrik</creatorcontrib><creatorcontrib>Nieminen, Markku S.</creatorcontrib><creatorcontrib>Sinisalo, Juha</creatorcontrib><creatorcontrib>Sorsa, Timo</creatorcontrib><creatorcontrib>Pussinen, Pirkko J.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Journal of clinical periodontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lahdentausta, Laura S. J.</au><au>Paju, Susanna</au><au>Mäntylä, Päivi</au><au>Buhlin, Kåre</au><au>Tervahartiala, Taina</au><au>Pietiäinen, Milla</au><au>Alfthan, Henrik</au><au>Nieminen, Markku S.</au><au>Sinisalo, Juha</au><au>Sorsa, Timo</au><au>Pussinen, Pirkko J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Saliva and serum biomarkers in periodontitis and coronary artery disease</atitle><jtitle>Journal of clinical periodontology</jtitle><addtitle>J Clin Periodontol</addtitle><date>2018-09</date><risdate>2018</risdate><volume>45</volume><issue>9</issue><spage>1045</spage><epage>1055</epage><pages>1045-1055</pages><issn>0303-6979</issn><issn>1600-051X</issn><eissn>1600-051X</eissn><abstract>Aim
Matrix metalloproteinase (MMP)‐8, MMP‐9, tissue inhibitor of matrix metalloproteinase (TIMP)‐1 and myeloperoxidase (MPO) participate in extracellular matrix breakdown both in periodontium and atherosclerotic plaques. We investigated the diagnostic value of serum and saliva biomarkers in periodontitis and acute coronary syndrome (ACS).
Materials and methods
The population was PAROGENE (n = 481), a random cohort of patients with an indication for coronary angiography. All patients underwent a clinical and radiographic oral examination. Groups consisting of periodontitis versus non‐periodontitis, and ACS versus non‐ACS patients were compared.
Results
Saliva MMP‐8, MMP‐9 and MPO provided significant area‐under‐curve (AUC) values for periodontitis, 0.69 (<0.001), 0.66 (<0.001) and 0.68 (<0.001), respectively. Serum MMP‐8, MMP‐9 and MPO levels distinguished ACS from non‐ACS patients with AUCs of 0.73 (<0.001), 0.58 (0.03) and 0.68 (<0.001), respectively. Periodontitis confounded the use of serum MMP‐9 in diagnostics of ACS. Cardiac status complicated the use of saliva TIMP‐1 in periodontal diagnostics. Saliva biomarkers could not be used in ACS diagnosis, and serum biomarkers were not useful in diagnosis of periodontitis.
Conclusions
MMP‐8, MMP‐9, TIMP‐1and MPO are valuable biomarkers for both ACS and periodontitis, but the selection of sample material is crucial; serum is suitable for ACS and saliva for periodontal diagnostic aid.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>29972696</pmid><doi>10.1111/jcpe.12976</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-4875-0682</orcidid><orcidid>https://orcid.org/0000-0003-4865-660X</orcidid></addata></record> |
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| subjects | acute coronary syndrome Acute coronary syndromes Angiography Arteriosclerosis biomarker Biomarkers Cardiovascular disease Coronary artery Dentistry Diagnosis Extracellular matrix Gum disease Heart diseases Matrix metalloproteinase Medicin och hälsovetenskap Metalloproteinase MMP‐8 MMP‐9 myeloperoxidase Periodontitis Periodontium Peroxidase Plaques Saliva serum TIMP‐1 Tissue inhibitor of metalloproteinases |
| title | Saliva and serum biomarkers in periodontitis and coronary artery disease |
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