Saliva and serum biomarkers in periodontitis and coronary artery disease

Aim Matrix metalloproteinase (MMP)‐8, MMP‐9, tissue inhibitor of matrix metalloproteinase (TIMP)‐1 and myeloperoxidase (MPO) participate in extracellular matrix breakdown both in periodontium and atherosclerotic plaques. We investigated the diagnostic value of serum and saliva biomarkers in periodontitis and acute coronary syndrome (ACS). Materials and methods The population was PAROGENE (n = 481), a random cohort of patients with an indication for coronary angiography. All patients underwent a clinical and radiographic oral examination. Groups consisting of periodontitis versus non‐periodontitis, and ACS versus non‐ACS patients were compared. Results Saliva MMP‐8, MMP‐9 and MPO provided significant area‐under‐curve (AUC) values for periodontitis, 0.69 (