A Prospective International Study on Adherence to Treatment in 305 Patients With Flaring SLE: Assessment by Drug Levels and Self‐Administered Questionnaires

A Prospective International Study on Adherence to Treatment in 305 Patients With Flaring SLE: Assessment by Drug Levels and Self‐Administered Questionnaires

Nonadherence to treatment is a major cause of lupus flares. Hydroxychloroquine (HCQ), a major medication in systemic lupus erythematosus, has a long half‐life and can be quantified by high‐performance liquid chromatography. This international study evaluated nonadherence in 305 lupus patients with f...

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Veröffentlicht in:Clinical pharmacology and therapeutics 2019-08, Vol.106 (2), p.374-382
Hauptverfasser: Costedoat‐Chalumeau, Nathalie, Houssiau, Frédéric, Izmirly, Peter, Guern, Véronique Le, Navarra, Sandra, Jolly, Meenakshi, Ruiz‐Irastorza, Guillermo, Baron, Gabriel, Hachulla, Eric, Agmon‐Levin, Nancy, Shoenfeld, Yehuda, Dall'Ara, Francesca, Buyon, Jill, Deligny, Christophe, Cervera, Ricard, Lazaro, Estibaliz, Bezanahary, Holy, Leroux, Gaëlle, Morel, Nathalie, Viallard, Jean‐François, Pineau, Christian, Galicier, Lionel, Vollenhoven, Ronald Van, Tincani, Angela, Nguyen, Hanh, Gondran, Guillaume, Zahr, Noel, Pouchot, Jacques, Piette, Jean‐Charles, Petri, Michelle, Isenberg, David
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Sprache:eng
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Life Sciences
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Zusammenfassung:Nonadherence to treatment is a major cause of lupus flares. Hydroxychloroquine (HCQ), a major medication in systemic lupus erythematosus, has a long half‐life and can be quantified by high‐performance liquid chromatography. This international study evaluated nonadherence in 305 lupus patients with flares using drug levels (HCQ 
ISSN:0009-9236
1532-6535
DOI:10.1002/cpt.1194