Thrombocytopenia is associated with severe retinopathy of prematurity

Retinopathy of prematurity (ROP) is characterized by abnormal retinal neovascularization in response to vessel loss. Platelets regulate angiogenesis and may influence ROP progression. In preterm infants, we assessed ROP and correlated with longitudinal postnatal platelet counts (n = 202). Any episod...

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Veröffentlicht in:	JCI INSIGHT 2018-10, Vol.3 (19)
Hauptverfasser:	Cakir, Bertan, Liegl, Raffael, Hellgren, Gunnel, Lundgren, Pia, Sun, Ye, Klevebro, Susanna, Löfqvist, Chatarina, Mannheimer, Clara, Cho, Steve, Poblete, Alexander, Duran, Rubi, Hallberg, Boubou, Canas, Jorge, Lorenz, Viola, Liu, Zhi-Jian, Sola-Visner, Martha C, Smith, Lois Eh, Hellström, Ann
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Animals, Newborn Clinical Medicine Disease Models, Animal endothelial-cells expression Female Humans Infant Infant, Extremely Premature Infant, Newborn Infant, Very Low Birth Weight Klinisk medicin Laser Therapy Male Mice Mice, 129 Strain Mice, Transgenic mouse Oxygen - administration & dosage Oxygen - toxicity oxygen-induced retinopathy p-selectin pathological platelet alpha-granules Platelet Count Platelet Transfusion Platelets proteins release Retina - pathology Retinal Neovascularization - blood Retinal Neovascularization - etiology Retinal Neovascularization - prevention & control Retinopathy Retinopathy of Prematurity - blood Retinopathy of Prematurity - etiology Retinopathy of Prematurity - therapy Retrospective Studies Thrombocytopenia - complications Thrombocytopenia - diagnosis Thrombocytopenia - therapy transfusions Vascular Biology Vascular Endothelial Growth Factor A - metabolism
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Zusammenfassung:	Retinopathy of prematurity (ROP) is characterized by abnormal retinal neovascularization in response to vessel loss. Platelets regulate angiogenesis and may influence ROP progression. In preterm infants, we assessed ROP and correlated with longitudinal postnatal platelet counts (n = 202). Any episode of thrombocytopenia (
ISSN:	2379-3708 2379-3708
DOI:	10.1172/jci.insight.99448