Effect of blood glucose level on standardized uptake value (SUV) in 18 F- FDG PET-scan: a systematic review and meta-analysis of 20,807 individual SUV measurements

To evaluate the effect of pre-scan blood glucose levels (BGL) on standardized uptake value (SUV) in F-FDG-PET scan. A literature review was performed in the MEDLINE, Embase, and Cochrane library databases. Multivariate regression analysis was performed on individual datum to investigate the correlation of BGL with SUV and SUV adjusting for sex, age, body mass index (BMI), diabetes mellitus diagnosis, F-FDG injected dose, and time interval. The ANOVA test was done to evaluate differences in SUV or SUV among five different BGL groups ( 200 mg/dl). Individual data for a total of 20,807 SUV and SUV measurements from 29 studies with 8380 patients was included in the analysis. Increased BGL is significantly correlated with decreased SUV and SUV in brain (p