Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306 473 UK Biobank participants

To evaluate the associations of a polygenic risk score and healthy lifestyle with incident stroke. Prospective population based cohort study. UK Biobank Study, UK. 306 473 men and women, aged 40-73 years, recruited between 2006 and 2010. Hazard ratios for a first stroke, estimated using Cox regressi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	BMJ (Online) 2018-10, Vol.363, p.k4168
Hauptverfasser:	Rutten-Jacobs, Loes Ca, Larsson, Susanna C, Malik, Rainer, Rannikmäe, Kristiina, Sudlow, Cathie L, Dichgans, Martin, Markus, Hugh S, Traylor, Matthew
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Body mass index Cardiovascular disease Cerebral Hemorrhage - epidemiology Cohort analysis Coronary vessels Exercise - physiology Family medical history Female Gender differences Genetic Predisposition to Disease Genomes Haplotypes Health behavior Health risk assessment Healthy Lifestyle Heart attacks Humans Incidence Lifestyles Male Medicin och hälsovetenskap Middle Aged Multifactorial Inheritance - genetics Myocardial Infarction - epidemiology Patient Compliance Polymorphism, Single Nucleotide - genetics Population studies Principal components analysis Prospective Studies Risk Factors Single-nucleotide polymorphism Stroke Stroke - epidemiology Stroke - genetics Subarachnoid hemorrhage Subarachnoid Hemorrhage - epidemiology United Kingdom
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	To evaluate the associations of a polygenic risk score and healthy lifestyle with incident stroke. Prospective population based cohort study. UK Biobank Study, UK. 306 473 men and women, aged 40-73 years, recruited between 2006 and 2010. Hazard ratios for a first stroke, estimated using Cox regression. A polygenic risk score of 90 single nucleotide polymorphisms previously associated with stroke was constructed at P
ISSN:	0959-8138 1756-1833 0959-535X 1756-1833
DOI:	10.1136/bmj.k4168