Mycophenolate mofetil treatment in patients with autoimmune hepatitis failing standard therapy with prednisolone and azathioprine

Data on rescue treatment of autoimmune hepatitis in patients that fail standard treatment are sparse. To report our long-term experience with mycophenolate mofetil. Retrospective study in 22 patients with autoimmune hepatitis who failed azathioprine and prednisolone due to adverse events (n = 14, 64...

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Veröffentlicht in:Digestive and liver disease 2019-02, Vol.51 (2), p.253-257
Hauptverfasser: Giannakopoulos, Georgios, Verbaan, Hans, Friis-Liby, Inga-Lill, Sangfelt, Per, Nyhlin, Nils, Almer, Sven
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Sprache:eng
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Zusammenfassung:Data on rescue treatment of autoimmune hepatitis in patients that fail standard treatment are sparse. To report our long-term experience with mycophenolate mofetil. Retrospective study in 22 patients with autoimmune hepatitis who failed azathioprine and prednisolone due to adverse events (n = 14, 64%), lack of remission (n = 5, 23%) or a combination (n = 3, 13%). Mycophenolate mofetil was started at a dose of 20 mg/kg/day and increased to a maximum of 3 g/day. Follow-up was 0–6 months in 7 patients; more than 12 months in 15 (68%) and more than 24 months in 10. Normal aminotransferase levels were obtained (n = 3) or maintained (n = 7) in 10 patients (45%) after three to 30 weeks. 12 patients (55%) were withdrawn during the first 6 months, due to adverse events. Three patients were switched to cyclosporine and one underwent liver transplantation. Successful treatment with mycophenolate mofetil continued in 10 patients (45%) for a median of 71 months (range 20–124). Of these, one stopped prednisolone, five have a prednisolone dose
ISSN:1590-8658
1878-3562
1878-3562
DOI:10.1016/j.dld.2018.10.004