Ex vivo culture of cells derived from circulating tumour cell xenograft to support small cell lung cancer research and experimental therapeutics

Background and Purpose Small cell lung cancer (SCLC) is an aggressive disease with median survival of

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Bibliographische Detailangaben
Veröffentlicht in:	British journal of pharmacology 2019-02, Vol.176 (3), p.436-450
Hauptverfasser:	Lallo, Alice, Gulati, Sakshi, Schenk, Maximilian W, Khandelwal, Garima, Berglund, Ulrika Warpman, Pateras, Ioannis S, Chester, Christopher P E, Pham, Therese M, Kalderen, Christina, Frese, Kristopher K, Gorgoulis, Vassilis G, Miller, Crispin, Blackhall, Fiona, Helleday, Thomas, Dive, Caroline
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biomarkers Cancer research Cell culture Cell Proliferation - drug effects Chemotherapy Dose-Response Relationship, Drug Drug Evaluation, Preclinical Drug Screening Assays, Antitumor Explants Humans Indazoles - chemistry Indazoles - pharmacology Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - pathology Medical research Mice Mice, Inbred Strains Mice, SCID Neoplasms, Experimental - drug therapy Neoplasms, Experimental - pathology Neoplastic Cells, Circulating - drug effects Neoplastic Cells, Circulating - pathology Neural coding Pharmacodynamics Phenotypes Research Paper Research Papers Small cell lung carcinoma Small Cell Lung Carcinoma - drug therapy Small Cell Lung Carcinoma - pathology Structure-Activity Relationship Sulfonamides - chemistry Sulfonamides - pharmacology Tumor Cells, Cultured Tumors Xenografts
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Beschreibung
Zusammenfassung:	Background and Purpose Small cell lung cancer (SCLC) is an aggressive disease with median survival of
ISSN:	0007-1188 1476-5381
DOI:	10.1111/bph.14542