Epigenome-wide meta-analysis of DNA methylation and childhood asthma

Epigenetic mechanisms, including methylation, can contribute to childhood asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease pathogenesis. We sought to identify differential DNA methylation in newborns and children related to childhood asthma. Within the Pregnancy...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2019-06, Vol.143 (6), p.2062-2074
Hauptverfasser:	Reese, Sarah E., Xu, Cheng-Jian, den Dekker, Herman T., Lee, Mi Kyeong, Sikdar, Sinjini, Ruiz-Arenas, Carlos, Merid, Simon K., Rezwan, Faisal I., Page, Christian M., Ullemar, Vilhelmina, Melton, Phillip E., Oh, Sam S., Yang, Ivana V., Burrows, Kimberley, Söderhäll, Cilla, Jima, Dereje D., Gao, Lu, Arathimos, Ryan, Küpers, Leanne K., Wielscher, Matthias, Rzehak, Peter, Lahti, Jari, Laprise, Catherine, Madore, Anne-Marie, Ward, James, Bennett, Brian D., Wang, Tianyuan, Bell, Douglas A., Vonk, Judith M., Håberg, Siri E., Zhao, Shanshan, Karlsson, Robert, Hollams, Elysia, Hu, Donglei, Richards, Adam J., Bergström, Anna, Sharp, Gemma C., Felix, Janine F., Bustamante, Mariona, Gruzieva, Olena, Maguire, Rachel L., Gilliland, Frank, Baïz, Nour, Nohr, Ellen A., Corpeleijn, Eva, Sebert, Sylvain, Karmaus, Wilfried, Grote, Veit, Kajantie, Eero, Magnus, Maria C., Örtqvist, Anne K., Eng, Celeste, Liu, Andrew H., Kull, Inger, Jaddoe, Vincent W.V., Sunyer, Jordi, Kere, Juha, Hoyo, Cathrine, Annesi-Maesano, Isabella, Arshad, Syed Hasan, Koletzko, Berthold, Brunekreef, Bert, Binder, Elisabeth B., Räikkönen, Katri, Reischl, Eva, Holloway, John W., Jarvelin, Marjo-Riitta, Snieder, Harold, Kazmi, Nabila, Breton, Carrie V., Murphy, Susan K., Pershagen, Göran, Anto, Josep Maria, Relton, Caroline L., Schwartz, David A., Burchard, Esteban G., Huang, Rae-Chi, Nystad, Wenche, Almqvist, Catarina, Henderson, A. John, Melén, Erik, Duijts, Liesbeth, Koppelman, Gerard H., London, Stephanie J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Asthma Asthma - genetics Blood Child Childhood Children Children & youth Consortia CpG islands CpG Islands - genetics Cross-Sectional Studies Deoxyribonucleic acid DNA DNA Methylation Drug development Epigenesis, Genetic Epigenetics Epigenome - genetics Epithelium ERG1 Potassium Channel - genetics Gene expression Genome-Wide Association Study Genomes Health risks Humans Immunosuppressive agents Infant, Newborn Interleukin-5 Receptor alpha Subunit - genetics Leukocytes (eosinophilic) Meta-analysis Methylation Neonates Newborn Pregnancy Quality control Respiratory tract
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Beschreibung
Zusammenfassung:	Epigenetic mechanisms, including methylation, can contribute to childhood asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease pathogenesis. We sought to identify differential DNA methylation in newborns and children related to childhood asthma. Within the Pregnancy And Childhood Epigenetics consortium, we performed epigenome-wide meta-analyses of school-age asthma in relation to CpG methylation (Illumina450K) in blood measured either in newborns, in prospective analyses, or cross-sectionally in school-aged children. We also identified differentially methylated regions. In newborns (8 cohorts, 668 cases), 9 CpGs (and 35 regions) were differentially methylated (epigenome-wide significance, false discovery rate
ISSN:	0091-6749 1097-6825 1097-6825
DOI:	10.1016/j.jaci.2018.11.043