Gα i2 Signaling Regulates Inflammasome Priming and Cytokine Production by Biasing Macrophage Phenotype Determination

Macrophages exist as innate immune subsets that exhibit phenotypic heterogeneity and functional plasticity. Their phenotypes are dictated by inputs from the tissue microenvironment. G-protein-coupled receptors are essential in transducing signals from the microenvironment, and heterotrimeric Gα sign...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of immunology (1950) 2019-03, Vol.202 (5), p.1510-1520
Hauptverfasser:	Vural, Ali, Nabar, Neel R, Hwang, Il-Young, Sohn, Silke, Park, Chung, Karlsson, Mikael C I, Blumer, Joe B, Kehrl, John H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Cytokines - biosynthesis GTP-Binding Protein alpha Subunit, Gi2 - deficiency GTP-Binding Protein alpha Subunit, Gi2 - immunology Inflammasomes - immunology Macrophages - immunology Mice Mice, Inbred C57BL Mice, Knockout Phenotype Signal Transduction - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!