Learning from the Fly Photoreceptor on How Synapses Integrate Gene Expression to Sustain Retina and Brain Function

Learning from the Fly Photoreceptor on How Synapses Integrate Gene Expression to Sustain Retina and Brain Function

Synapse dysfunction is thought to contribute to neurodegenerative diseases. In this issue of Neuron, Tsai et al. (2019) uncover how membrane phospholipid biosynthesis regulates Drosophila photoreceptor (PR) degeneration and the synaptic vesicle pool through a transcriptional-translational feedback l...

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Veröffentlicht in:Neuron (Cambridge, Mass.) Mass.), 2019-02, Vol.101 (4), p.548-550
Hauptverfasser: Bazan, Nicolas G., Gordon, William C.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Brain
Drosophila
Gene expression
Lipids
Macular degeneration
Mutation
Neurodegeneration
Neurodegenerative diseases
Phospholipids
Retina
Retinal degeneration
Synapses
Synaptic Vesicles
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Zusammenfassung:Synapse dysfunction is thought to contribute to neurodegenerative diseases. In this issue of Neuron, Tsai et al. (2019) uncover how membrane phospholipid biosynthesis regulates Drosophila photoreceptor (PR) degeneration and the synaptic vesicle pool through a transcriptional-translational feedback loop from the synaptic terminal to the nucleus. Synapse dysfunction is thought to contribute to neurodegenerative diseases. In this issue of Neuron, Tsai et al. (2019) uncover how membrane phospholipid biosynthesis regulates Drosophila photoreceptor (PR) degeneration and the synaptic vesicle pool through a transcriptional-translational feedback loop from the synaptic terminal to the nucleus.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2019.02.004