Differential Treatments Based on Drug-induced Gene Expression Signatures and Longitudinal Systemic Lupus Erythematosus Stratification

Systemic lupus erythematosus (SLE) is a heterogeneous disease with unpredictable patterns of activity. Patients with similar activity levels may have different prognosis and molecular abnormalities. In this study, we aimed to measure the main differences in drug-induced gene expression signatures ac...

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Veröffentlicht in:	Scientific reports 2019-10, Vol.9 (1), p.15502, Article 15502
Hauptverfasser:	Toro-Domínguez, Daniel, Lopez-Domínguez, Raúl, García Moreno, Adrián, Villatoro-García, Juan A., Martorell-Marugán, Jordi, Goldman, Daniel, Petri, Michelle, Wojdyla, Daniel, Pons-Estel, Bernardo A., Isenberg, David, Morales-Montes de Oca, Gabriela, Trejo-Zambrano, María Isabel, García González, Benjamín, Rosetti, Florencia, Gómez-Martín, Diana, Romero-Díaz, Juanita, Carmona-Sáez, Pedro, Alarcón-Riquelme, Marta E.
Format:	Artikel
Sprache:	eng
Schlagworte:	38 631/114/1305 631/114/2404 631/114/2415 692/699/249/1313/1613 Autoimmune diseases Case-Control Studies Cluster Analysis Cohort Studies Drug development Drug efficacy Female Gene expression Humanities and Social Sciences Humans Learning algorithms Longitudinal Studies Lupus Lupus Erythematosus, Systemic - classification Lupus Erythematosus, Systemic - drug therapy Lupus Erythematosus, Systemic - genetics Male multidisciplinary Oxidative stress Patients Science Science (multidisciplinary) Severity of Illness Index Systemic lupus erythematosus TOR protein Transcriptome - drug effects
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