Association of genetic variants related to plasma fatty acids with type 2 diabetes mellitus and glycaemic traits: a Mendelian randomisation study

Association of genetic variants related to plasma fatty acids with type 2 diabetes mellitus and glycaemic traits: a Mendelian randomisation study

Aims/hypothesis Epidemiological data on the associations of circulating fatty acid levels with type 2 diabetes are inconsistent. We conducted a two-sample Mendelian randomisation study to explore the causal associations of plasma levels of ten fatty acids with type 2 diabetes and glycaemic traits. M...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Diabetologia 2020-01, Vol.63 (1), p.116-123
Hauptverfasser: Yuan, Shuai, Larsson, Susanna C.
Format: Artikel
Sprache:eng
Schlagworte:
Arachidonic acid
Beta cells
Consortia
Diabetes
Diabetes mellitus (non-insulin dependent)
Eicosapentaenoic acid
Epidemiology
Fasting
Fatty acids
Fish oils
Genetic analysis
Genetic diversity
Genetic variants
Genomes
Glucose
Glycaemic traits
Human Physiology
Insulin
Internal Medicine
Laboratory testing
Linoleic acid
Linolenic acid
Medicine
Medicine & Public Health
Mendelian randomisation
Metabolic Diseases
Oleic acid
Palmitoleic acid
Plasma levels
Single-nucleotide polymorphism
Stearic acid
Type 2 diabetes
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Aims/hypothesis Epidemiological data on the associations of circulating fatty acid levels with type 2 diabetes are inconsistent. We conducted a two-sample Mendelian randomisation study to explore the causal associations of plasma levels of ten fatty acids with type 2 diabetes and glycaemic traits. Methods Thirteen SNPs associated with circulating levels of ten individual fatty acids at the genome-wide significance level ( p  
ISSN:0012-186X
1432-0428
1432-0428
DOI:10.1007/s00125-019-05019-0