Vitamin B-6 Intake Is Modestly Associated with Arsenic Methylation in Uruguayan Children with Low-Level Arsenic Exposure
Detoxification of inorganic arsenic (iAs) occurs when it methylates to form monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA). Lower proportions of urinary iAs and MMA, and higher proportions of DMA indicate efficient methylation. The role of B-vitamins in iAs methylation in children with...
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| creator | Desai, Gauri Vahter, Marie Queirolo, Elena I Peregalli, Fabiana Mañay, Nelly Millen, Amy E Yu, Jihnhee Browne, Richard W Kordas, Katarzyna |
| description | Detoxification of inorganic arsenic (iAs) occurs when it methylates to form monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA). Lower proportions of urinary iAs and MMA, and higher proportions of DMA indicate efficient methylation. The role of B-vitamins in iAs methylation in children with low-level arsenic exposure is understudied.
Our study objective was to assess the association between B-vitamin intake and iAs methylation in children with low-level arsenic exposure ( |
| doi_str_mv | 10.1093/jn/nxz331 |
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Our study objective was to assess the association between B-vitamin intake and iAs methylation in children with low-level arsenic exposure (<50 µg/L in water; urinary arsenic 5–50 µg/L).
We conducted a cross-sectional study in 290 ~7-y-old children in Montevideo. Intake of thiamin, riboflavin, niacin, vitamin B-6, and vitamin B-12 was calculated by averaging 2 nonconsecutive 24-h recalls. Total urinary arsenic concentration was measured as the sum of urinary iAs, MMA, and DMA, and adjusted for urinary specific gravity; iAs methylation was measured as urinary percentage As, percentage MMA, and percentage DMA. Arsenic concentrations from household water sources were assessed. Linear regressions tested the relationships between individual energy-adjusted B-vitamins and iAs methylation.
Median (range) arsenic concentrations in urine and water were 9.9 (2.2–48.7) and 0.45 (0.1–18.9) µg/L, respectively. The median (range) of urinary percentage iAs, percentage MMA, and percentage DMA was 10.6% (0.0–33.8), 9.7% (2.6–24.8), and 79.1% (58.5–95.4), respectively. The median (range) intake levels of thiamin, riboflavin, niacin, and vitamin B-6 were 0.81 (0.19–2.56), 1.0 (0.30–2.24), 8.6 (3.5–23.3), and 0.67 (0.25–1.73) mg/1000 kcal, respectively, whereas those of folate and vitamin B-12 were 216 (75–466) and 1.7 (0.34–8.3) µg/1000 kcal, respectively. Vitamin B-6 intake was inversely associated with urinary percentage MMA (β = –1.60; 95% CI: –3.07, –0.15). No other statistically significant associations were observed.
Although vitamin B-6 intake was inversely associated with urinary percentage MMA, our findings suggest limited support for a relation between B-vitamin intake and iAs methylation in children exposed to low-level arsenic.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/nxz331</identifier><identifier>PMID: 31913474</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Arsenic ; Arsenic - analysis ; Arsenic - metabolism ; Arsenic - urine ; Arsenicals - urine ; B-vitamins ; Cacodylic Acid - urine ; Child ; Children ; Childrens health ; Cross-Sectional Studies ; Cyanocobalamin ; Detoxification ; Diet ; Dimethylarsinic acid ; DNA methylation ; Energy Intake ; Environmental Exposure ; Exposure ; Female ; Folic acid ; Humans ; Inactivation, Metabolic - drug effects ; inorganic arsenic ; low-level exposure ; Male ; Methylation ; Niacin - administration & dosage ; Nutritional Epidemiology ; Pyridoxine ; Riboflavin ; Riboflavin - administration & dosage ; Specific gravity ; Statistical analysis ; Thiamine ; Thiamine - administration & dosage ; Uruguay ; Vitamin B ; Vitamin B 12 - administration & dosage ; Vitamin B 6 - administration & dosage ; Vitamins ; Water - chemistry</subject><ispartof>The Journal of nutrition, 2020-05, Vol.150 (5), p.1223-1229</ispartof><rights>2020 American Society for Nutrition.</rights><rights>Copyright © The Author(s) 2020. 2020</rights><rights>Copyright © The Author(s) 2020.</rights><rights>Copyright American Institute of Nutrition May 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-9d0181bcfe242f4dcc6f6e06d94d8372f6664ec8274cac9521d5be2a9c1413873</citedby><cites>FETCH-LOGICAL-c514t-9d0181bcfe242f4dcc6f6e06d94d8372f6664ec8274cac9521d5be2a9c1413873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,550,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31913474$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:143656205$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Desai, Gauri</creatorcontrib><creatorcontrib>Vahter, Marie</creatorcontrib><creatorcontrib>Queirolo, Elena I</creatorcontrib><creatorcontrib>Peregalli, Fabiana</creatorcontrib><creatorcontrib>Mañay, Nelly</creatorcontrib><creatorcontrib>Millen, Amy E</creatorcontrib><creatorcontrib>Yu, Jihnhee</creatorcontrib><creatorcontrib>Browne, Richard W</creatorcontrib><creatorcontrib>Kordas, Katarzyna</creatorcontrib><title>Vitamin B-6 Intake Is Modestly Associated with Arsenic Methylation in Uruguayan Children with Low-Level Arsenic Exposure</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>Detoxification of inorganic arsenic (iAs) occurs when it methylates to form monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA). Lower proportions of urinary iAs and MMA, and higher proportions of DMA indicate efficient methylation. The role of B-vitamins in iAs methylation in children with low-level arsenic exposure is understudied.
Our study objective was to assess the association between B-vitamin intake and iAs methylation in children with low-level arsenic exposure (<50 µg/L in water; urinary arsenic 5–50 µg/L).
We conducted a cross-sectional study in 290 ~7-y-old children in Montevideo. Intake of thiamin, riboflavin, niacin, vitamin B-6, and vitamin B-12 was calculated by averaging 2 nonconsecutive 24-h recalls. Total urinary arsenic concentration was measured as the sum of urinary iAs, MMA, and DMA, and adjusted for urinary specific gravity; iAs methylation was measured as urinary percentage As, percentage MMA, and percentage DMA. Arsenic concentrations from household water sources were assessed. Linear regressions tested the relationships between individual energy-adjusted B-vitamins and iAs methylation.
Median (range) arsenic concentrations in urine and water were 9.9 (2.2–48.7) and 0.45 (0.1–18.9) µg/L, respectively. The median (range) of urinary percentage iAs, percentage MMA, and percentage DMA was 10.6% (0.0–33.8), 9.7% (2.6–24.8), and 79.1% (58.5–95.4), respectively. The median (range) intake levels of thiamin, riboflavin, niacin, and vitamin B-6 were 0.81 (0.19–2.56), 1.0 (0.30–2.24), 8.6 (3.5–23.3), and 0.67 (0.25–1.73) mg/1000 kcal, respectively, whereas those of folate and vitamin B-12 were 216 (75–466) and 1.7 (0.34–8.3) µg/1000 kcal, respectively. Vitamin B-6 intake was inversely associated with urinary percentage MMA (β = –1.60; 95% CI: –3.07, –0.15). No other statistically significant associations were observed.
Although vitamin B-6 intake was inversely associated with urinary percentage MMA, our findings suggest limited support for a relation between B-vitamin intake and iAs methylation in children exposed to low-level arsenic.</description><subject>Arsenic</subject><subject>Arsenic - analysis</subject><subject>Arsenic - metabolism</subject><subject>Arsenic - urine</subject><subject>Arsenicals - urine</subject><subject>B-vitamins</subject><subject>Cacodylic Acid - urine</subject><subject>Child</subject><subject>Children</subject><subject>Childrens health</subject><subject>Cross-Sectional Studies</subject><subject>Cyanocobalamin</subject><subject>Detoxification</subject><subject>Diet</subject><subject>Dimethylarsinic acid</subject><subject>DNA methylation</subject><subject>Energy Intake</subject><subject>Environmental Exposure</subject><subject>Exposure</subject><subject>Female</subject><subject>Folic acid</subject><subject>Humans</subject><subject>Inactivation, Metabolic - drug effects</subject><subject>inorganic arsenic</subject><subject>low-level exposure</subject><subject>Male</subject><subject>Methylation</subject><subject>Niacin - administration & dosage</subject><subject>Nutritional Epidemiology</subject><subject>Pyridoxine</subject><subject>Riboflavin</subject><subject>Riboflavin - administration & dosage</subject><subject>Specific gravity</subject><subject>Statistical analysis</subject><subject>Thiamine</subject><subject>Thiamine - administration & dosage</subject><subject>Uruguay</subject><subject>Vitamin B</subject><subject>Vitamin B 12 - administration & dosage</subject><subject>Vitamin B 6 - administration & dosage</subject><subject>Vitamins</subject><subject>Water - chemistry</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp9kU9vEzEQxS0EoqFw4AsgS3DhsNRee727F6Q0KhApFRfK1XLs2cbpxg62N3_49BhtiKiEONny_N4bzxuEXlPygZKWXa3dlTv8ZIw-QRNacVoISshTNCGkLAtGhbhAL2JcE0Iob5vn6ILRljJe8wk6fLdJbazD14XAc5fUA-B5xLfeQEz9EU9j9NqqBAbvbVrhaYjgrMa3kFbHXiXrHc7quzDcD-qoHJ6tbG8CuBFf-H2xgB30Z-HNYevjEOAletapPsKr03mJ7j7dfJt9KRZfP89n00WhK8pT0RpCG7rUHZS87LjRWnQCiDAtNw2ry04IwUE3Zc210m1VUlMtoVStppyypmaXqBh94x62w1Jug92ocJReWXl6esg3kDkOzknmP458rmzAaHApqP6R7HHF2ZW89ztZ07ZhlGWDtyeD4H8MOUW59kNweUZZ8jxMRepWZOr9SOngYwzQnTtQIn8vVa6dHJea2Td_f-lM_tliBt6NgB-2__VhIwY5752FIKO24DQYG0Anabz9h-oX2VS-ow</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Desai, Gauri</creator><creator>Vahter, Marie</creator><creator>Queirolo, Elena I</creator><creator>Peregalli, Fabiana</creator><creator>Mañay, Nelly</creator><creator>Millen, Amy E</creator><creator>Yu, Jihnhee</creator><creator>Browne, Richard W</creator><creator>Kordas, Katarzyna</creator><general>Elsevier Inc</general><general>Oxford University Press</general><general>American Institute of Nutrition</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20200501</creationdate><title>Vitamin B-6 Intake Is Modestly Associated with Arsenic Methylation in Uruguayan Children with Low-Level Arsenic Exposure</title><author>Desai, Gauri ; 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Lower proportions of urinary iAs and MMA, and higher proportions of DMA indicate efficient methylation. The role of B-vitamins in iAs methylation in children with low-level arsenic exposure is understudied.
Our study objective was to assess the association between B-vitamin intake and iAs methylation in children with low-level arsenic exposure (<50 µg/L in water; urinary arsenic 5–50 µg/L).
We conducted a cross-sectional study in 290 ~7-y-old children in Montevideo. Intake of thiamin, riboflavin, niacin, vitamin B-6, and vitamin B-12 was calculated by averaging 2 nonconsecutive 24-h recalls. Total urinary arsenic concentration was measured as the sum of urinary iAs, MMA, and DMA, and adjusted for urinary specific gravity; iAs methylation was measured as urinary percentage As, percentage MMA, and percentage DMA. Arsenic concentrations from household water sources were assessed. Linear regressions tested the relationships between individual energy-adjusted B-vitamins and iAs methylation.
Median (range) arsenic concentrations in urine and water were 9.9 (2.2–48.7) and 0.45 (0.1–18.9) µg/L, respectively. The median (range) of urinary percentage iAs, percentage MMA, and percentage DMA was 10.6% (0.0–33.8), 9.7% (2.6–24.8), and 79.1% (58.5–95.4), respectively. The median (range) intake levels of thiamin, riboflavin, niacin, and vitamin B-6 were 0.81 (0.19–2.56), 1.0 (0.30–2.24), 8.6 (3.5–23.3), and 0.67 (0.25–1.73) mg/1000 kcal, respectively, whereas those of folate and vitamin B-12 were 216 (75–466) and 1.7 (0.34–8.3) µg/1000 kcal, respectively. Vitamin B-6 intake was inversely associated with urinary percentage MMA (β = –1.60; 95% CI: –3.07, –0.15). No other statistically significant associations were observed.
Although vitamin B-6 intake was inversely associated with urinary percentage MMA, our findings suggest limited support for a relation between B-vitamin intake and iAs methylation in children exposed to low-level arsenic.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>31913474</pmid><doi>10.1093/jn/nxz331</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; SWEPUB Freely available online |
| subjects | Arsenic Arsenic - analysis Arsenic - metabolism Arsenic - urine Arsenicals - urine B-vitamins Cacodylic Acid - urine Child Children Childrens health Cross-Sectional Studies Cyanocobalamin Detoxification Diet Dimethylarsinic acid DNA methylation Energy Intake Environmental Exposure Exposure Female Folic acid Humans Inactivation, Metabolic - drug effects inorganic arsenic low-level exposure Male Methylation Niacin - administration & dosage Nutritional Epidemiology Pyridoxine Riboflavin Riboflavin - administration & dosage Specific gravity Statistical analysis Thiamine Thiamine - administration & dosage Uruguay Vitamin B Vitamin B 12 - administration & dosage Vitamin B 6 - administration & dosage Vitamins Water - chemistry |
| title | Vitamin B-6 Intake Is Modestly Associated with Arsenic Methylation in Uruguayan Children with Low-Level Arsenic Exposure |
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