Vitamin B-6 Intake Is Modestly Associated with Arsenic Methylation in Uruguayan Children with Low-Level Arsenic Exposure

Detoxification of inorganic arsenic (iAs) occurs when it methylates to form monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA). Lower proportions of urinary iAs and MMA, and higher proportions of DMA indicate efficient methylation. The role of B-vitamins in iAs methylation in children with...

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Veröffentlicht in:	The Journal of nutrition 2020-05, Vol.150 (5), p.1223-1229
Hauptverfasser:	Desai, Gauri, Vahter, Marie, Queirolo, Elena I, Peregalli, Fabiana, Mañay, Nelly, Millen, Amy E, Yu, Jihnhee, Browne, Richard W, Kordas, Katarzyna
Format:	Artikel
Sprache:	eng
Schlagworte:	Arsenic Arsenic - analysis Arsenic - metabolism Arsenic - urine Arsenicals - urine B-vitamins Cacodylic Acid - urine Child Children Childrens health Cross-Sectional Studies Cyanocobalamin Detoxification Diet Dimethylarsinic acid DNA methylation Energy Intake Environmental Exposure Exposure Female Folic acid Humans Inactivation, Metabolic - drug effects inorganic arsenic low-level exposure Male Methylation Niacin - administration & dosage Nutritional Epidemiology Pyridoxine Riboflavin Riboflavin - administration & dosage Specific gravity Statistical analysis Thiamine Thiamine - administration & dosage Uruguay Vitamin B Vitamin B 12 - administration & dosage Vitamin B 6 - administration & dosage Vitamins Water - chemistry
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Zusammenfassung:	Detoxification of inorganic arsenic (iAs) occurs when it methylates to form monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA). Lower proportions of urinary iAs and MMA, and higher proportions of DMA indicate efficient methylation. The role of B-vitamins in iAs methylation in children with low-level arsenic exposure is understudied. Our study objective was to assess the association between B-vitamin intake and iAs methylation in children with low-level arsenic exposure (
ISSN:	0022-3166 1541-6100
DOI:	10.1093/jn/nxz331