Correlation Between Immunoglobulin Dose Administered and Plasma Neutralization of Streptococcal Superantigens in Patients With Necrotizing Soft Tissue Infections

Abstract Analyses of plasma collected pre- and postadministration of intravenous immunoglobulin (IVIG) from patients with group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r = −.67, P

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Veröffentlicht in:	Clinical infectious diseases 2020-10, Vol.71 (7), p.1772-1775
Hauptverfasser:	Bergsten, Helena, Madsen, Martin Bruun, Bergey, Francois, Hyldegaard, Ole, Skrede, Steinar, Arnell, Per, Oppegaard, Oddvar, Itzek, Andreas, Perner, Anders, Svensson, Mattias, Norrby-Teglund, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Fasciitis, Necrotizing - drug therapy Humans Immunoglobulins, Intravenous Medicin och hälsovetenskap Plasma Soft Tissue Infections - drug therapy Streptococcal Infections - drug therapy Streptococcus pyogenes Superantigens
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Beschreibung
Zusammenfassung:	Abstract Analyses of plasma collected pre- and postadministration of intravenous immunoglobulin (IVIG) from patients with group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r = −.67, P
ISSN:	1058-4838 1537-6591 1537-6591
DOI:	10.1093/cid/ciaa022