Cytokines of the IL‐17 family in psoriasis

Cytokines of the IL‐17 family in psoriasis

Summary Various immune cells and their messenger substances influence the development of psoriasis. Cytokines of the IL‐17 family are of particular importance. In addition to IL‐17A, which plays a central role in the pathogenesis of psoriasis, other subtypes of the IL‐17 family also have a proinflam...

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Veröffentlicht in:JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT 2020-07, Vol.18 (7), p.675-681
Hauptverfasser: Lauffer, Felix, Eyerich, Kilian, Boehncke, Wolf‐Henning, Asadullah, Khusru, Beissert, Stefan, Ghoreschi, Kamran, Schön, Michael P.
Format: Artikel
Sprache:eng
Schlagworte:
Cytokines
Immunopathogenesis
Inflammation
Psoriasis
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Zusammenfassung:Summary Various immune cells and their messenger substances influence the development of psoriasis. Cytokines of the IL‐17 family are of particular importance. In addition to IL‐17A, which plays a central role in the pathogenesis of psoriasis, other subtypes of the IL‐17 family also have a proinflammatory effect. This review provides an up‐to‐date overview of the immunopathogenesis of psoriasis with regard to the six IL‐17 subtypes, in particular their physiological and pathogenic properties, as well as their significance for psoriasis therapy.
ISSN:1610-0379
1610-0387
DOI:10.1111/ddg.14124