Genomewide Association Study of Severe Covid-19 with Respiratory Failure

During the peak of hospitalizations of patients with severe Covid-19 in Italy and Spain in March, a group of researchers in these and other countries obtained and analyzed samples, resulting in the identification of two chromosomal loci associated with the disorder.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2020-10, Vol.383 (16), p.1522-1534
Hauptverfasser:	Ellinghaus, David, Degenhardt, Frauke, Bujanda, Luis, Buti, Maria, Albillos, Agustín, Invernizzi, Pietro, Fernández, Javier, Prati, Daniele, Baselli, Guido, Asselta, Rosanna, Grimsrud, Marit M, Milani, Chiara, Aziz, Fátima, Kässens, Jan, May, Sandra, Wendorff, Mareike, Wienbrandt, Lars, Uellendahl-Werth, Florian, Zheng, Tenghao, Yi, Xiaoli, de Pablo, Raúl, Chercoles, Adolfo G, Palom, Adriana, Garcia-Fernandez, Alba-Estela, Rodriguez-Frias, Francisco, Zanella, Alberto, Bandera, Alessandra, Protti, Alessandro, Aghemo, Alessio, Lleo, Ana, Biondi, Andrea, Caballero-Garralda, Andrea, Gori, Andrea, Tanck, Anja, Carreras Nolla, Anna, Latiano, Anna, Fracanzani, Anna Ludovica, Peschuck, Anna, Julià, Antonio, Pesenti, Antonio, Voza, Antonio, Jiménez, David, Mateos, Beatriz, Nafria Jimenez, Beatriz, Quereda, Carmen, Paccapelo, Cinzia, Gassner, Christoph, Angelini, Claudio, Cea, Cristina, Solier, Aurora, Pestaña, David, Muñiz-Diaz, Eduardo, Sandoval, Elena, Paraboschi, Elvezia M, Navas, Enrique, García Sánchez, Félix, Ceriotti, Ferruccio, Martinelli-Boneschi, Filippo, Peyvandi, Flora, Blasi, Francesco, Téllez, Luis, Blanco-Grau, Albert, Hemmrich-Stanisak, Georg, Grasselli, Giacomo, Costantino, Giorgio, Cardamone, Giulia, Foti, Giuseppe, Aneli, Serena, Kurihara, Hayato, ElAbd, Hesham, My, Ilaria, Galván-Femenia, Iván, Martín, Javier, Erdmann, Jeanette, Ferrusquía-Acosta, Jose, Garcia-Etxebarria, Koldo, Izquierdo-Sanchez, Laura, Bettini, Laura R, Sumoy, Lauro, Terranova, Leonardo, Moreira, Leticia, Santoro, Luigi, Scudeller, Luigia, Mesonero, Francisco, Roade, Luisa, Rühlemann, Malte C, Schaefer, Marco, Carrabba, Maria, Riveiro-Barciela, Mar, Figuera Basso, Maria E, Valsecchi, Maria G, Hernandez-Tejero, María, Acosta-Herrera, Marialbert, D'Angiò, Mariella, Baldini, Marina, Cazzaniga, Marina, Schulzky, Martin, Cecconi, Maurizio, Wittig, Michael, Ciccarelli, Michele
Format:	Artikel
Sprache:	eng
Schlagworte:	ABO Blood-Group System - genetics ABO system Age Aged Association analysis Blood & organ donations Blood group A Blood group O Blood groups Case-Control Studies CCR9 protein Chromosome 3 Chromosome 9 Chromosomes, Human, Pair 3 - genetics Chromosomes, Human, Pair 9 - genetics Coronaviridae Coronaviruses COVID-19 COVID-19 - complications COVID-19 - genetics Disease Drug dosages Epidemics Ethics Female Genetic factors Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Hospitals Humans Informed consent Italy Male Medical research Middle Aged Mortality Multigene Family Original Pandemics Pathogenesis Phlebotomy Polymorphism, Single Nucleotide Quality control Respiratory failure Respiratory Insufficiency - genetics RNA polymerase SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Single-nucleotide polymorphism Spain Susceptibility Systematic review Ventilators
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Beschreibung
Zusammenfassung:	During the peak of hospitalizations of patients with severe Covid-19 in Italy and Spain in March, a group of researchers in these and other countries obtained and analyzed samples, resulting in the identification of two chromosomal loci associated with the disorder.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2020283