Age-Induced Reduction in Human Lipolysis: A Potential Role for Adipocyte Noradrenaline Degradation

Age-Induced Reduction in Human Lipolysis: A Potential Role for Adipocyte Noradrenaline Degradation

Gao et al. report that the observed reduction in adipose lipolysis with age in women could be explained by an upregulation of the catecholamine-degradation pathway in subcutaneous adipocytes. However, in contrast to findings in mice, these pathways are enriched in adipocytes and not in immune cells,...

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Veröffentlicht in:Cell metabolism 2020-07, Vol.32 (1), p.1-3
Hauptverfasser: Gao, Hui, Arner, Peter, Beauchef, Gallic, Guéré, Christelle, Vie, Katell, Dahlman, Ingrid, Mejhert, Niklas, Rydén, Mikael
Format: Artikel
Sprache:eng
Schlagworte:
adipocytes
age
body weight
transcriptome
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Zusammenfassung:Gao et al. report that the observed reduction in adipose lipolysis with age in women could be explained by an upregulation of the catecholamine-degradation pathway in subcutaneous adipocytes. However, in contrast to findings in mice, these pathways are enriched in adipocytes and not in immune cells, suggesting species-specific differences in aging mechanisms.
ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2020.06.007