Myocyte-Specific Upregulation of ACE2 in Cardiovascular Disease: Implications for SARS-CoV-2–Mediated Myocarditis

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Veröffentlicht in:	CIRCULATION 2020-08, Vol.142 (7), p.708-710, Article CIRCULATIONAHA.120.047911
Hauptverfasser:	Tucker, Nathan R., Chaffin, Mark, Bedi, Kenneth C., Papangeli, Irinna, Akkad, Amer-Denis, Arduini, Alessandro, Hayat, Sikander, Eraslan, Gökcen, Muus, Christoph, Bhattacharyya, Roby P., Stegmann, Christian M., Margulies, Kenneth B., Ellinor, Patrick T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin-Converting Enzyme 2 Betacoronavirus - isolation & purification Betacoronavirus - pathogenicity Cardiomyopathy, Dilated - genetics Cardiomyopathy, Dilated - pathology Cardiomyopathy, Hypertrophic - genetics Cardiomyopathy, Hypertrophic - pathology Cathepsin L - genetics Cathepsin L - metabolism Coronavirus Infections - complications Coronavirus Infections - pathology Coronavirus Infections - virology Correspondence COVID-19 Heart Ventricles - metabolism Humans Life Sciences Myocarditis - diagnosis Myocarditis - etiology Myocardium - metabolism Pandemics Peptidyl-Dipeptidase A - chemistry Peptidyl-Dipeptidase A - genetics Peptidyl-Dipeptidase A - metabolism Pneumonia, Viral - complications Pneumonia, Viral - pathology Pneumonia, Viral - virology Protease Inhibitors - pharmacology RNA-Seq SARS-CoV-2 Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Up-Regulation - drug effects
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Zusammenfassung:	Supplemental Digital Content is available in the text.
ISSN:	0009-7322 1524-4539
DOI:	10.1161/CIRCULATIONAHA.120.047911