Genetic mechanisms of critical illness in COVID-19

Host-mediated lung inflammation is present 1 , and drives mortality 2 , in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development 3 . Here we report the results of the Gen...

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Veröffentlicht in:	Nature (London) 2021-03, Vol.591 (7848), p.92-98
Hauptverfasser:	Pairo-Castineira, Erola, Clohisey, Sara, Klaric, Lucija, Bretherick, Andrew D., Rawlik, Konrad, Pasko, Dorota, Walker, Susan, Parkinson, Nick, Fourman, Max Head, Russell, Clark D., Furniss, James, Richmond, Anne, Gountouna, Elvina, Wrobel, Nicola, Harrison, David, Wang, Bo, Wu, Yang, Meynert, Alison, Griffiths, Fiona, Oosthuyzen, Wilna, Kousathanas, Athanasios, Moutsianas, Loukas, Yang, Zhijian, Zhai, Ranran, Zheng, Chenqing, Grimes, Graeme, Beale, Rupert, Millar, Jonathan, Shih, Barbara, Keating, Sean, Zechner, Marie, Haley, Chris, Porteous, David J., Hayward, Caroline, Yang, Jian, Knight, Julian, Summers, Charlotte, Shankar-Hari, Manu, Klenerman, Paul, Turtle, Lance, Ho, Antonia, Moore, Shona C., Hinds, Charles, Horby, Peter, Nichol, Alistair, Maslove, David, Ling, Lowell, McAuley, Danny, Montgomery, Hugh, Walsh, Timothy, Pereira, Alexandre C., Renieri, Alessandra, Shen, Xia, Ponting, Chris P., Fawkes, Angie, Tenesa, Albert, Caulfield, Mark, Scott, Richard, Rowan, Kathy, Murphy, Lee, Openshaw, Peter J. M., Semple, Malcolm G., Law, Andrew, Vitart, Veronique, Wilson, James F., Baillie, J. Kenneth
Format:	Artikel
Sprache:	eng
Schlagworte:	2',5'-Oligoadenylate Synthetase - genetics 45 45/22 45/23 45/43 45/61 631/208/205/2138 631/250/248 631/326/596/4130 692/699/255/2514 Antiviral agents Biobanks CC chemokine receptors CCR2 protein Chromosome 12 Chromosome 19 Chromosome 21 Chromosomes Chromosomes, Human, Pair 12 - genetics Chromosomes, Human, Pair 19 - genetics Chromosomes, Human, Pair 21 - genetics Clinical trials Consortia Coronaviruses COVID-19 COVID-19 - genetics COVID-19 - pathology COVID-19 - physiopathology Critical Care Critical Illness Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - genetics Disease Drug Repositioning Female Gene expression Gene loci Genetic diversity Genetic variance Genetics Genome-wide association studies Genome-Wide Association Study Genomes Genotype & phenotype Hospitalization Hospitals Humanities and Social Sciences Humans Illnesses Inflammation Inflammation - genetics Inflammation - pathology Inflammation - physiopathology Intensive care Intensive care units Interferon Kinases Lung - pathology Lung - physiopathology Lung - virology Lungs Macrophages Male Meta-analysis Monocyte chemoattractant protein 1 Monocytes Mortality multidisciplinary Multigene Family - genetics Peptidase Peptidases Population Protein-tyrosine kinase Pulmonary arteries Randomization Receptor, Interferon alpha-beta - genetics Receptors Receptors, CCR2 - genetics Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Target recognition Transcriptomes TYK2 Kinase - genetics Tyk2 protein Tyrosine United Kingdom Viral diseases
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