Trial of Dexamethasone for Chronic Subdural Hematoma

In a trial that compared a 2-week course of dexamethasone with placebo in patients with a chronic subdural hematoma, a favorable outcome on the modified Rankin scale at 6 months was more common in the placebo group than in the dexamethasone group, but repeat surgery to evacuate a hematoma was perfor...

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Veröffentlicht in:	The New England journal of medicine 2020-12, Vol.383 (27), p.2616-2627
Hauptverfasser:	Hutchinson, Peter J, Edlmann, Ellie, Bulters, Diederik, Zolnourian, Ardalan, Holton, Patrick, Suttner, Nigel, Agyemang, Kevin, Thomson, Simon, Anderson, Ian A, Al-Tamimi, Yahia Z, Henderson, Duncan, Whitfield, Peter C, Gherle, Monica, Brennan, Paul M, Allison, Annabel, Thelin, Eric P, Tarantino, Silvia, Pantaleo, Beatrice, Caldwell, Karen, Davis-Wilkie, Carol, Mee, Harry, Warburton, Elizabeth A, Barton, Garry, Chari, Aswin, Marcus, Hani J, King, Andrew T, Belli, Antonio, Myint, Phyo K, Wilkinson, Ian, Santarius, Thomas, Turner, Carole, Bond, Simon, Kolias, Angelos G
Format:	Artikel
Sprache:	eng
Schlagworte:	Activities of daily living Administration, Oral Aged Blood Brain Clinical trials Combined Modality Therapy Consent Dexamethasone Dexamethasone - administration & dosage Dexamethasone - adverse effects Dexamethasone - therapeutic use Disabled Persons Dura mater Enrollments Female Glucocorticoids - administration & dosage Glucocorticoids - adverse effects Glucocorticoids - therapeutic use Hematoma Hematoma, Subdural, Chronic - complications Hematoma, Subdural, Chronic - drug therapy Hematoma, Subdural, Chronic - mortality Hematoma, Subdural, Chronic - surgery Humans Intention to Treat Analysis Male Meninges Middle Aged Patients Questionnaires Reoperation - statistics & numerical data Severity of Illness Index Steroids Surgery Treatment Outcome
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Beschreibung
Zusammenfassung:	In a trial that compared a 2-week course of dexamethasone with placebo in patients with a chronic subdural hematoma, a favorable outcome on the modified Rankin scale at 6 months was more common in the placebo group than in the dexamethasone group, but repeat surgery to evacuate a hematoma was performed more frequently in the placebo group.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2020473