Five-Year Outcomes of PFO Closure or Antiplatelet Therapy for Cryptogenic Stroke

In the initial report of the Gore REDUCE trial of patent foramen ovale closure, with a median follow-up of 3.2 years, 18 patients had stroke recurrence (6 in the PFO closure group and 12 in the antiplatelet-only group). After a median follow-up of 5 years, 20 patients had stroke recurrence, with the...

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Veröffentlicht in:	The New England journal of medicine 2021-03, Vol.384 (10), p.970-971
Hauptverfasser:	Kasner, Scott E, Rhodes, John F, Andersen, Grethe, Iversen, Helle K, Nielsen-Kudsk, Jens E, Settergren, Magnus, Sjöstrand, Christina, Roine, Risto O, Hildick-Smith, David, Spence, J. David, Søndergaard, Lars
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiac arrhythmia Follow-Up Studies Foramen Ovale, Patent - complications Foramen Ovale, Patent - therapy Humans Ischemic Stroke - etiology Ischemic Stroke - prevention & control Medicin och hälsovetenskap Patients Platelet Aggregation Inhibitors - adverse effects Platelet Aggregation Inhibitors - therapeutic use Secondary Prevention Septal Occluder Device - adverse effects Stroke
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Zusammenfassung:	In the initial report of the Gore REDUCE trial of patent foramen ovale closure, with a median follow-up of 3.2 years, 18 patients had stroke recurrence (6 in the PFO closure group and 12 in the antiplatelet-only group). After a median follow-up of 5 years, 20 patients had stroke recurrence, with the two additional strokes occurring in the PFO closure group.
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMc2033779