Implementation of iMiDEV™, a new fully automated microfluidic platform for radiopharmaceutical production
iMiDEV™ microfluidic system is a new automated tool for a small-scale production of radiopharmaceuticals. This new radiochemistry module utilizes microfluidic cassettes capable of producing diversified radiopharmaceuticals in liquid phase reactions in an automated synthesizer. The user interface is...
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| Veröffentlicht in: | Lab on a chip 2021, Vol.21 (11), p.2272-2282 |
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| creator | Ovdiichuk, Olga Mallapura, Hemantha Pineda, Florian Hourtané, Virginie Långström, Bengt Halldin, Christer Nag, Sangram Maskali, Fatiha Karcher, Gilles Collet, Charlotte |
| description | iMiDEV™ microfluidic system is a new automated tool for a small-scale production of radiopharmaceuticals. This new radiochemistry module utilizes microfluidic cassettes capable of producing diversified radiopharmaceuticals in liquid phase reactions in an automated synthesizer. The user interface is intuitive and designed to give the operator all the information required and to allow driving the synthesis either manually or fully automatically. In this work, we have demonstrated liquid phase reaction and presented the first results of an efficient fully automated [
18
F]NaF radiosynthesis on the iMiDEV™ platform. Different parameters such as a type of cyclotron targets, initial activity, concentration and volume of the fluoride-18 targetry have been investigated in order to elaborate the optimised radiolabelling of the ligand. Single and double sodium [
18
F]fluoride synthesis procedures have been successfully developed using two chambers of the cassette. A single-dose of radiotracer was produced in an average radiochemical yield of 87% (decay corrected) within 8 min and quality control tests were performed as per European Pharmacopoeia.
We present an efficient fully automated sodium [
18
F]fluoride radiosynthesis on a new iMiDEV™ cassette-based microfluidic platform. |
| doi_str_mv | 10.1039/d1lc00148e |
| format | Article |
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18
F]NaF radiosynthesis on the iMiDEV™ platform. Different parameters such as a type of cyclotron targets, initial activity, concentration and volume of the fluoride-18 targetry have been investigated in order to elaborate the optimised radiolabelling of the ligand. Single and double sodium [
18
F]fluoride synthesis procedures have been successfully developed using two chambers of the cassette. A single-dose of radiotracer was produced in an average radiochemical yield of 87% (decay corrected) within 8 min and quality control tests were performed as per European Pharmacopoeia.
We present an efficient fully automated sodium [
18
F]fluoride radiosynthesis on a new iMiDEV™ cassette-based microfluidic platform.</description><identifier>ISSN: 1473-0197</identifier><identifier>ISSN: 1473-0189</identifier><identifier>EISSN: 1473-0189</identifier><identifier>DOI: 10.1039/d1lc00148e</identifier><identifier>PMID: 33912890</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Automation ; Cassettes ; Chemical Sciences ; Chemical synthesis ; Cyclotrons ; Fluorides ; Liquid phases ; Microfluidics ; Quality control ; Radioactive tracers ; Radiochemistry ; Radiolabelling</subject><ispartof>Lab on a chip, 2021, Vol.21 (11), p.2272-2282</ispartof><rights>Copyright Royal Society of Chemistry 2021</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-ff6ae0257d7c8e2eaa320067f4e58d88f8bbe308665a56ab894744cf215571213</citedby><cites>FETCH-LOGICAL-c519t-ff6ae0257d7c8e2eaa320067f4e58d88f8bbe308665a56ab894744cf215571213</cites><orcidid>0000-0001-5478-1365 ; 0000-0002-9669-6967 ; 0000-0002-3594-3960</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,552,778,782,883,4012,27906,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33912890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.univ-lorraine.fr/hal-03215066$$DView record in HAL$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-454491$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:146489153$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Ovdiichuk, Olga</creatorcontrib><creatorcontrib>Mallapura, Hemantha</creatorcontrib><creatorcontrib>Pineda, Florian</creatorcontrib><creatorcontrib>Hourtané, Virginie</creatorcontrib><creatorcontrib>Långström, Bengt</creatorcontrib><creatorcontrib>Halldin, Christer</creatorcontrib><creatorcontrib>Nag, Sangram</creatorcontrib><creatorcontrib>Maskali, Fatiha</creatorcontrib><creatorcontrib>Karcher, Gilles</creatorcontrib><creatorcontrib>Collet, Charlotte</creatorcontrib><title>Implementation of iMiDEV™, a new fully automated microfluidic platform for radiopharmaceutical production</title><title>Lab on a chip</title><addtitle>Lab Chip</addtitle><description>iMiDEV™ microfluidic system is a new automated tool for a small-scale production of radiopharmaceuticals. This new radiochemistry module utilizes microfluidic cassettes capable of producing diversified radiopharmaceuticals in liquid phase reactions in an automated synthesizer. The user interface is intuitive and designed to give the operator all the information required and to allow driving the synthesis either manually or fully automatically. In this work, we have demonstrated liquid phase reaction and presented the first results of an efficient fully automated [
18
F]NaF radiosynthesis on the iMiDEV™ platform. Different parameters such as a type of cyclotron targets, initial activity, concentration and volume of the fluoride-18 targetry have been investigated in order to elaborate the optimised radiolabelling of the ligand. Single and double sodium [
18
F]fluoride synthesis procedures have been successfully developed using two chambers of the cassette. A single-dose of radiotracer was produced in an average radiochemical yield of 87% (decay corrected) within 8 min and quality control tests were performed as per European Pharmacopoeia.
We present an efficient fully automated sodium [
18
F]fluoride radiosynthesis on a new iMiDEV™ cassette-based microfluidic platform.</description><subject>Automation</subject><subject>Cassettes</subject><subject>Chemical Sciences</subject><subject>Chemical synthesis</subject><subject>Cyclotrons</subject><subject>Fluorides</subject><subject>Liquid phases</subject><subject>Microfluidics</subject><subject>Quality control</subject><subject>Radioactive tracers</subject><subject>Radiochemistry</subject><subject>Radiolabelling</subject><issn>1473-0197</issn><issn>1473-0189</issn><issn>1473-0189</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>D8T</sourceid><recordid>eNp10kGP1CAUAODGaNx19eJdQ-JFzVahUArHyczobjLGi-6VUAouu7R0objZu7_En-YvkdpxjCZegDy-vDweryieIvgGQczfdsgpCBFh-l5xjEiDS4gYv3848-aoeBTjVTY1oexhcYQxRxXj8Li4Pu9Hp3s9THKyfgDeAPvBbrYXP759PwUSDPoWmOTcHZBp8r2cdAd6q4I3LtnOKjA6ORkfepAXEGRn_XgpQy-VTpNV0oEx-C6pOfnj4oGRLuon-_2k-Pxu-2l9Vu4-vj9fr3alqhGfSmOo1LCqm65RTFdaSlxBSBtDdM06xgxrW40ho7SWNZUt46QhRJkK1XWDKoRPinLJG2_1mFoxBtvLcCe8tGIfus4nLQitCJ396X_9xl6shA9fREqC1ITwmb9a-KV0f9mz1U7MMYhzKZDSr7N9udjchZuk4yR6G5V2Tg7apyiq_OKGc8Z5pi_-oVc-hSE3KitcV5QSTrJ6vaj8BTEGbQ4VICjmaRAbtFv_moZtxs_3KVPb6-5Af39_Bs8WEKI63P4ZJ_wTrRW6RQ</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Ovdiichuk, Olga</creator><creator>Mallapura, Hemantha</creator><creator>Pineda, Florian</creator><creator>Hourtané, Virginie</creator><creator>Långström, Bengt</creator><creator>Halldin, Christer</creator><creator>Nag, Sangram</creator><creator>Maskali, Fatiha</creator><creator>Karcher, Gilles</creator><creator>Collet, Charlotte</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7TB</scope><scope>7U5</scope><scope>8FD</scope><scope>FR3</scope><scope>L7M</scope><scope>7X8</scope><scope>1XC</scope><scope>ACNBI</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>DF2</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0001-5478-1365</orcidid><orcidid>https://orcid.org/0000-0002-9669-6967</orcidid><orcidid>https://orcid.org/0000-0002-3594-3960</orcidid></search><sort><creationdate>2021</creationdate><title>Implementation of iMiDEV™, a new fully automated microfluidic platform for radiopharmaceutical production</title><author>Ovdiichuk, Olga ; Mallapura, Hemantha ; Pineda, Florian ; Hourtané, Virginie ; Långström, Bengt ; Halldin, Christer ; Nag, Sangram ; Maskali, Fatiha ; Karcher, Gilles ; Collet, Charlotte</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-ff6ae0257d7c8e2eaa320067f4e58d88f8bbe308665a56ab894744cf215571213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Automation</topic><topic>Cassettes</topic><topic>Chemical Sciences</topic><topic>Chemical synthesis</topic><topic>Cyclotrons</topic><topic>Fluorides</topic><topic>Liquid phases</topic><topic>Microfluidics</topic><topic>Quality control</topic><topic>Radioactive tracers</topic><topic>Radiochemistry</topic><topic>Radiolabelling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ovdiichuk, Olga</creatorcontrib><creatorcontrib>Mallapura, Hemantha</creatorcontrib><creatorcontrib>Pineda, Florian</creatorcontrib><creatorcontrib>Hourtané, Virginie</creatorcontrib><creatorcontrib>Långström, Bengt</creatorcontrib><creatorcontrib>Halldin, Christer</creatorcontrib><creatorcontrib>Nag, Sangram</creatorcontrib><creatorcontrib>Maskali, Fatiha</creatorcontrib><creatorcontrib>Karcher, Gilles</creatorcontrib><creatorcontrib>Collet, Charlotte</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>SWEPUB Uppsala universitet full text</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Uppsala universitet</collection><collection>SwePub Articles full text</collection><jtitle>Lab on a chip</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ovdiichuk, Olga</au><au>Mallapura, Hemantha</au><au>Pineda, Florian</au><au>Hourtané, Virginie</au><au>Långström, Bengt</au><au>Halldin, Christer</au><au>Nag, Sangram</au><au>Maskali, Fatiha</au><au>Karcher, Gilles</au><au>Collet, Charlotte</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Implementation of iMiDEV™, a new fully automated microfluidic platform for radiopharmaceutical production</atitle><jtitle>Lab on a chip</jtitle><addtitle>Lab Chip</addtitle><date>2021</date><risdate>2021</risdate><volume>21</volume><issue>11</issue><spage>2272</spage><epage>2282</epage><pages>2272-2282</pages><issn>1473-0197</issn><issn>1473-0189</issn><eissn>1473-0189</eissn><abstract>iMiDEV™ microfluidic system is a new automated tool for a small-scale production of radiopharmaceuticals. This new radiochemistry module utilizes microfluidic cassettes capable of producing diversified radiopharmaceuticals in liquid phase reactions in an automated synthesizer. The user interface is intuitive and designed to give the operator all the information required and to allow driving the synthesis either manually or fully automatically. In this work, we have demonstrated liquid phase reaction and presented the first results of an efficient fully automated [
18
F]NaF radiosynthesis on the iMiDEV™ platform. Different parameters such as a type of cyclotron targets, initial activity, concentration and volume of the fluoride-18 targetry have been investigated in order to elaborate the optimised radiolabelling of the ligand. Single and double sodium [
18
F]fluoride synthesis procedures have been successfully developed using two chambers of the cassette. A single-dose of radiotracer was produced in an average radiochemical yield of 87% (decay corrected) within 8 min and quality control tests were performed as per European Pharmacopoeia.
We present an efficient fully automated sodium [
18
F]fluoride radiosynthesis on a new iMiDEV™ cassette-based microfluidic platform.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>33912890</pmid><doi>10.1039/d1lc00148e</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-5478-1365</orcidid><orcidid>https://orcid.org/0000-0002-9669-6967</orcidid><orcidid>https://orcid.org/0000-0002-3594-3960</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1473-0197 |
| ispartof | Lab on a chip, 2021, Vol.21 (11), p.2272-2282 |
| issn | 1473-0197 1473-0189 1473-0189 |
| language | eng |
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| source | SWEPUB Freely available online; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Automation Cassettes Chemical Sciences Chemical synthesis Cyclotrons Fluorides Liquid phases Microfluidics Quality control Radioactive tracers Radiochemistry Radiolabelling |
| title | Implementation of iMiDEV™, a new fully automated microfluidic platform for radiopharmaceutical production |
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