The trans-ancestral genomic architecture of glycemic traits

Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature genetics 2021-06, Vol.53 (6), p.840-860
Hauptverfasser:	Marenne, Gaëlle, Horikoshi, Momoko, Chu, Audrey Y., Hong, Jaeyoung, Hottenga, Jouke-Jan, Kaakinen, Marika A., Moreno-Macias, Hortensia, Nolte, Ilja M., Raulerson, Chelsea K., Chen, Brian H., Hai, Yang, He, Jing, Heianza, Yoriko, Huang, Tao, Huerta-Chagoya, Alicia, Jensen, Richard A., Lange, Leslie A., Langefeld, Carl D., Li, Man, Nag, Abhishek, Pistis, Giorgio, Raffield, Laura, Robertson, Neil R., Rueedi, Rico, Ryan, Kathleen, Saxena, Richa, van der Most, Peter J., Wang, Nan, Warren, Helen R., Wilsgaard, Tom, Wong, Andrew, Zafarmand, Mohammad Hadi, Baldassarre, Damiano, Beekman, Marian, Bergman, Richard N., Bornstein, Stefan R., Campbell, Archie, Chang, Yi Cheng, Eiriksdottir, Gudny, Han, Sohee, Hartman, Catharina A., Ichihara, Sahoko, Katsuya, Tomohiro, Khor, Chiea Chuen, Kolcic, Ivana, Kuulasmaa, Teemu, Lemaitre, Rozenn N., Lin, Shih-Yi, Linneberg, Allan, Matsuda, Fumihiko, Moon, Sanghoon, Ohyagi, Yasumasa, Qi, Qibin, Sandow, Kevin, Thuesen, Betina, van Dam, Rob M., Willems van Dijk, Ko, Adair, Linda S., Boehnke, Michael, Bønnelykke, Klaus, Boomsma, D. I., Buchanan, Thomas A., Chambers, John C., Chasman, Daniel I., Chen, Yii-Der Ida, Collins, Francis S., Cucca, Francesco, de Silva, H. Janaka, Ferrucci, Luigi, Florez, Jose C., Franks, Paul W., Grimsgaard, Sameline, Guo, Xiuqing, Huang, Wei, Kato, Norihiro, Koistinen, Heikki A., Kuh, Diana, Kumari, Meena, Launer, Lenore J., Mook-Kanamori, Dennis O., Pedersen, Oluf, Pramstaller, Peter P., Province, Michael A., Psaty, Bruce M., Rosendaal, Frits R., Shu, Xiao-ou, Tai, E. Shyong, Timpson, Nicholas J., Tusie, Teresa, Uusitupa, Matti, Vrijkotte, Tanja G. M., Wei, Wen B., Willemsen, Gonneke, Wong, Tien-Yin, Xiang, Anny H., Yokota, Mitsuhiro, Zeggini, Eleftheria, McCarthy, Mark I., Dupuis, Josée, Parker, Stephen C. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	45/43 631/208 692/699 African Americans Agriculture allele Alleles Animal Genetics and Genomics Biological effects Biomedical and Life Sciences Biomedicine Blood Glucose Blood Glucose - genetics Cancer Research Caucasian chromosomal mapping Clinical Medicine Demographic aspects Diabetes Diabetes mellitus (non-insulin dependent) Endocrinology and Diabetes Endokrinologi och diabetes Epigenesis, Genetic Equivalence European Continental Ancestry Group Europeans Fasting Gene expression Gene Expression Profiling Gene Function Gene mapping Genetic aspects genetic epigenesis genetics Genome, Human Genome-wide association studies Genome-Wide Association Study Genomes Genomics Glucose glucose blood level Glycated Hemoglobin - metabolism Glycated Hemoglobin A Glycemic index glycosylated hemoglobin Health aspects Hemoglobin Heterogeneity Hispanic people human Human Genetics human genome Humans Insulin Insulin resistance Klinisk medicin Laboratory testing Life Sciences Medical and Health Sciences Medicin och hälsovetenskap Meta-analysis metabolism multifactorial inheritance Multifactorial Inheritance - genetics Pathophysiology Physical Chromosome Mapping quantitative trait Quantitative Trait Loci Quantitative Trait Loci - genetics quantitative trait locus Quantitative Trait, Heritable White People - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P
ISSN:	1061-4036 1546-1718 1546-1718
DOI:	10.1038/s41588-021-00852-9