Treatment of Multisystem Inflammatory Syndrome in Children

An observational cohort study evaluated immunomodulatory therapy of multisystem inflammatory syndrome in children by comparing IVIG, IVIG plus glucocorticoids, or glucocorticoids alone. The investigators found no evidence of the superiority of any of the three therapies, although significant differe...

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Veröffentlicht in:	The New England journal of medicine 2021-07, Vol.385 (1), p.11-22
Hauptverfasser:	McArdle, Andrew J, Vito, Ortensia, Patel, Harsita, Seaby, Eleanor G, Shah, Priyen, Wilson, Clare, Broderick, Claire, Nijman, Ruud, Tremoulet, Adriana H, Munblit, Daniel, Ulloa-Gutierrez, Rolando, Carter, Michael J, De, Tisham, Hoggart, Clive, Whittaker, Elizabeth, Herberg, Jethro A, Kaforou, Myrsini, Cunnington, Aubrey J, Levin, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Allergy Aneurysms Antibodies, Viral Child Child, Preschool Childhood Diseases Children Cohort Studies Confidence Intervals Coronavirus Coronaviruses COVID-19 COVID-19 - drug therapy COVID-19 - immunology COVID-19 - mortality COVID-19 - therapy Disease Drug Therapy, Combination Female Globulins Glucocorticoids Glucocorticoids - therapeutic use Hospitalization Humans Immunoglobulins Immunoglobulins, Intravenous - therapeutic use Immunology Immunology General Immunomodulation Infections Infectious Disease Inflammation Intravenous administration Laboratories Male Mechanical ventilation Medicin och hälsovetenskap Multisystem inflammatory syndrome in children Original Patients Pediatrics Pediatrics General Propensity Score Proteins Regression Analysis Respiration, Artificial SARS-CoV-2 - immunology Severe acute respiratory syndrome coronavirus 2 Statistical analysis Systemic Inflammatory Response Syndrome - drug therapy Systemic Inflammatory Response Syndrome - immunology Systemic Inflammatory Response Syndrome - mortality Systemic Inflammatory Response Syndrome - therapy Treatment Outcome Veins & arteries Ventilation
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Beschreibung
Zusammenfassung:	An observational cohort study evaluated immunomodulatory therapy of multisystem inflammatory syndrome in children by comparing IVIG, IVIG plus glucocorticoids, or glucocorticoids alone. The investigators found no evidence of the superiority of any of the three therapies, although significant differences may emerge as more data accrue.
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa2102968