Phosphate Concentrations and Modifying Factors in Healthy Children From 12 to 24 Months of Age

Phosphate homeostasis and its modifiers in early childhood are inadequately characterized. To determine physiological plasma phosphate concentration and modifying factors in healthy infants at 12 to 24 months of age. This study included 525 healthy infants (53% girls), who participated in a randomized vitamin D intervention trial and received daily vitamin D3 supplementation of either 10 or 30 μg from age 2 weeks to 24 months. Biochemical parameters were measured at 12 and 24 months. Dietary phosphate intake was determined at 12 months. Plasma phosphate concentrations at 12 and 24 months of age. Mean (SD) phosphate concentration decreased from 12 months (1.9 ± 0.15 mmol/L) to 24 months (1.6 ± 0.17 mmol/L) of age (P 0.472 for all). Plasma iron was associated positively with plasma phosphate at both time points (B, 0.006 and 0.005; 95% CI, 0.004-0.009 and 0.002-0.008; P