Assessing the role of cortisol in cancer: a wide-ranged Mendelian randomisation study

Background Cortisol’s immunosuppressive, obesogenic, and hyperglycaemic effects suggest that it may play a role in cancer development. However, whether cortisol increases cancer risk is not known. We investigated the potential causal association between plasma cortisol and risk of overall and common...

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Veröffentlicht in:	British journal of cancer 2021-09, Vol.125 (7), p.1025-1029
Hauptverfasser:	Larsson, Susanna C., Lee, Wei-Hsuan, Kar, Siddhartha, Burgess, Stephen, Allara, Elias
Format:	Artikel
Sprache:	eng
Schlagworte:	692/4028/67 692/499 Biological Specimen Banks Biomedical and Life Sciences Biomedicine Breast Cancer Research Consortia Cortisol Drug Resistance Endometrial cancer Endometrium Epidemiology Genetic diversity Genome-wide association studies Genome-Wide Association Study Genomes Hormones Humans Hydrocortisone - blood Lung cancer Mendelian Randomization Analysis - methods Molecular Medicine Neoplasms - blood Neoplasms - genetics Oncology Plasma Polymorphism, Single Nucleotide Prostate Skin cancer United Kingdom
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Zusammenfassung:	Background Cortisol’s immunosuppressive, obesogenic, and hyperglycaemic effects suggest that it may play a role in cancer development. However, whether cortisol increases cancer risk is not known. We investigated the potential causal association between plasma cortisol and risk of overall and common site-specific cancers using Mendelian randomisation. Methods Three genetic variants associated with morning plasma cortisol levels at the genome-wide significance level ( P
ISSN:	0007-0920 1532-1827 1532-1827
DOI:	10.1038/s41416-021-01505-8