Global characteristics and outcomes of SARS-CoV-2 infection in children and adolescents with cancer (GRCCC): a cohort study

Previous studies have shown that children and adolescents with COVID-19 generally have mild disease. Children and adolescents with cancer, however, can have severe disease when infected with respiratory viruses. In this study, we aimed to understand the clinical course and outcomes of SARS-CoV-2 inf...

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Veröffentlicht in:	LANCET ONCOLOGY 2021-10, Vol.22 (10), p.1416-1426
Hauptverfasser:	Bhakta, Nickhill, Chen, Yichen, Vedaraju, Yuvanesh, Faughnan, Lane, Homsi, Maysam R, Muniz-Talavera, Hilmarie, Friedrich, Paola, Agulnik, Asya, Jeha, Sima, Lam, Catherine, Dalvi, Rashmi, Hessissen, Laila, Santana, Victor M, Sullivan, Michael, Bouffet, Eric, Devidas, Meenakshi, Rodriguez-Galindo, Carlos, Casanovas, Alejandra, Garcia Velazquez, Alejandra, Chang, Alicia, F. Sampaio, Alessandra Lamenha, González Prieto, Almudena, Alcasabas, Ana Patricia, Colombini, Antonella, Kattamis, Antonis, Bhattacharyya, Arpita, Alimi, Aurélia, Vakrmanova, Barbora, Brethon, Benoit, Nolasco Monteiro, Carla, Vezina, Catherine, Meazza, Cristina, Ortiz-Morales, Daniel, Arce Cabrera, Daniela, Ramírez-Rivera, Diana, Calle Jara, Doris A, Janic, Dragana, Lopez, Enrique, Thebault, Eric, Galaverna, Federica, Antillon-Klussmann, Federico, Barriga, Francisco, Tamayo Pedraza, Gabriela, Alias, Hamidah, Boudiaf, Houda, Maia, Iris, Jazbec, Janez, Lazic, Jelena, Contreras González, Johanny Carolina, Fuster, José L, Malic Tudor, Karolina, Georgantzi, Kleopatra, P Schultz, Kris Ann, Ureña Horno, Laura, Shalaby, Lobna, Nunes Silva, Luciana, Sisinni, Luisa, Hammad, Mahmoud, Zubieta A, C Marcela, Drozdowski, María Constanza, Kourti, Maria, Palladino, Marcela María, Miranda Madrazo, Maria R, Avilés-Robles, Martha J, Mendes Lins, Mecneide, Fatih Orhan, Mehmet, Jerónimo, Mónica, Varas Palma, Mónica, Rafie Raza, Muhammad, M Justin, Mulindwa, Domínguez-Pinilla, Nerea, André, Nicolas, Zacasa Vargas, Pamela, Olate Mellado, Paola, Yola Gassant, Pascale, Diaz Romero, Paulina, Kebudi, Rejin, Boranbayeva, Riza, Vasquez, Roberto, Rosado, Roy Enrique, Gómez, Sandra, Gunasekera, Sanjeeva, Makkeyah, Sara M, Buyukkapu Bay, Sema, M Gómez, Sergio, Bouttefroy, Séverine, Abouelnaga, Sherif, Torres, Silvio Fabio, Cesaro, Simone, Nunes, Sofia, Saliyeva, Symbat, Velasquez, Thelma, Hnin, Tint Myo, Norén-Nyström, Ulrika, Baretta, Valentina, Jimenez-Antolinez, Yajaira Valentine, Gandemer, Virginie, Lotero, Viviana, Margaryan, Yeva, Syed, Yumna
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescence Adolescent Adolescents Adults Blood cancer Cancer Cell number Child Child, Preschool Children Children & youth Cohort analysis Cohort Studies Coronaviruses COVID-19 COVID-19 - mortality COVID-19 vaccines Data collection Data entry Demography Diagnosis Fatalities Female Hematopoietic stem cells Hospitals Humans Illnesses Immunization Infant Infant, Newborn Infections Laboratories Leukocytes (neutrophilic) Low income groups Lymphocytes Male Mortality Neoplasms - mortality Neutropenia Oncology Patients Pediatrics Population Risk Factors SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index Stem cell transplantation Teenagers Viral infections
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Zusammenfassung:	Previous studies have shown that children and adolescents with COVID-19 generally have mild disease. Children and adolescents with cancer, however, can have severe disease when infected with respiratory viruses. In this study, we aimed to understand the clinical course and outcomes of SARS-CoV-2 infection in children and adolescents with cancer. We did a cohort study with data from 131 institutions in 45 countries. We created the Global Registry of COVID-19 in Childhood Cancer to capture de-identified data pertaining to laboratory-confirmed SARS-CoV-2 infections in children and adolescents (
ISSN:	1470-2045 1474-5488
DOI:	10.1016/S1470-2045(21)00454-X