Lower plasma total tau in adolescent psychosis: Involvement of the orbitofrontal cortex

Schizophrenia is thought to be a neurodevelopmental disorder with neuronal migration, differentiation and maturation disturbances. Tau is a microtubule-associated protein with a crucial role in these processes. Lower circulating tau levels have been reported in adults with schizophrenia, but this as...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of psychiatric research 2021-12, Vol.144, p.255-261
Hauptverfasser:	Andreou, Dimitrios, Jørgensen, Kjetil Nordbø, Nerland, Stener, Smelror, Runar Elle, Wedervang-Resell, Kirsten, Johannessen, Cecilie Haggag, Myhre, Anne Margrethe, Andreassen, Ole A., Blennow, Kaj, Zetterberg, Henrik, Agartz, Ingrid
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescence Adolescent Adult Antipsychotic Agents - therapeutic use bipolar blood biomarkers cerebral-cortex cerebrospinal-fluid tau cognitive impairment deficit disorder Early-onset psychosis frontotemporal dementia Humans injury Magnetic Resonance Imaging - methods MRI Neurosciences Neurovetenskaper Orbitofrontal cortex Prefrontal Cortex Psychiatry Psychotic Disorders - diagnostic imaging Psychotic Disorders - drug therapy Psykiatri schizophrenia Schizophrenia - diagnostic imaging Schizophrenia - drug therapy Tau
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Schizophrenia is thought to be a neurodevelopmental disorder with neuronal migration, differentiation and maturation disturbances. Tau is a microtubule-associated protein with a crucial role in these processes. Lower circulating tau levels have been reported in adults with schizophrenia, but this association has not been investigated in adolescent psychosis. We aimed to test the hypotheses that a) adolescents with early-onset psychosis (EOP; age of onset
ISSN:	0022-3956 1879-1379
DOI:	10.1016/j.jpsychires.2021.10.031