Morning chronotype and digestive tract cancers: Mendelian randomization study

Morning chronotype has been associated with a reduced risk of prostate and breast cancer. However, few studies have examined whether chronotype is associated with digestive tract cancer risk. We conducted a Mendelian randomization (MR) study to assess the associations of chronotype with major digest...

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Veröffentlicht in:	International journal of cancer 2023-02, Vol.152 (4), p.697-704
Hauptverfasser:	Yuan, Shuai, Mason, Amy M., Titova, Olga E., Vithayathil, Mathew, Kar, Siddhartha, Chen, Jie, Li, Xue, Burgess, Stephen, Larsson, Susanna C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biliary tract Biobanks Body mass index Breast cancer Cancer Chronotype Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics digestive system cancer Gastric cancer Gastrointestinal Neoplasms - epidemiology Gastrointestinal Neoplasms - genetics Gastrointestinal tract Genetic analysis Genetic diversity Genome-Wide Association Study Genomes Humans Male Medical research Mendelian randomization Mendelian Randomization Analysis Meta-analysis Polymorphism, Single Nucleotide Prostate cancer Risk Factors Sleep disorders Stomach
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Zusammenfassung:	Morning chronotype has been associated with a reduced risk of prostate and breast cancer. However, few studies have examined whether chronotype is associated with digestive tract cancer risk. We conducted a Mendelian randomization (MR) study to assess the associations of chronotype with major digestive tract cancers. A total of 317 independent genetic variants associated with chronotype at the genome‐wide significance level (P
ISSN:	0020-7136 1097-0215 1097-0215
DOI:	10.1002/ijc.34284